Associations Between Prenatal Arsenic Exposure with Adverse Pregnancy Outcome and Child Mortality

Details

• Personal Author:
  Ahsan H ; Argos M ; Baron JA ; Graziano JH ; Harjes J ; Hore SK ; Islam T ; Parvez F ; Sarwar G ; Shahriar MH ; Shih Y-H ; Yunus M
• Description:
  BACKGROUND: Chronic arsenic exposure is a public health concern in many parts of the world, with elevated concentrations in groundwater posing a threat to millions of people. Arsenic is associated with various cancers and an array of chronic diseases; however, the relationship with adverse pregnancy outcomes and child mortality is less established. OBJECTIVES: We evaluated associations between individual-level prenatal arsenic exposure with adverse pregnancy outcomes and child mortality in a pregnancy study among 498 women nested in a larger population-based cohort in rural Bangladesh. METHODS: Creatinine-adjusted urinary total arsenic concentration, a comprehensive measure of exposure from water, food, and air sources, reflective of the prenatal period was available for participants. Self-reported pregnancy outcomes (livebirth, stillbirth, spontaneous/elective abortion) were ascertained. Generalized estimating equations, accounting for multiple pregnancies of participants, were used to estimate odds ratios and 95% confidence intervals in relation to adverse pregnancy outcomes. Vital status of livebirths was subsequently ascertained through November 2015. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals in relation to child mortality. RESULTS: We observed a significant association between prenatal arsenic exposure and the risk of stillbirth (greater than median; adjusted OR = 2.50; 95% CI = 1.04, 6.01). We also observed elevated risk of child mortality (greater than median; adjusted HR = 1.92; 95% CI = 0.78, 4.68) in relation to prenatal arsenic exposure. CONCLUSIONS: Prospective studies should continue to evaluate prenatal and early life health effects of arsenic exposure and arsenic remediation strategies for women of child-bearing age. [Description provided by NIOSH]
• Subjects:
  Arsenic Environmental Exposure Inorganic Chemicals Mortality Neoplasms Occupational Health Pregnancy Public Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Arsenic Poisoning Cancer Children Environmental Exposure Exposure Levels Hazards Health Effects Humans Models Mortality Rates Prenatal Exposure Public Health Risk Factors

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; New Hampshire ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  456-461
• Volume:
  158
• NIOSHTIC Number:
  nn:20053193
• Citation:
  Environ Res 2017 Oct; 158:456-461
• Contact Point Address:
  Maria Argosa, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612
• Email:
  argos@uic.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e6e07bae53a065c6ea35ed712b23b553a0f8c930812886b3c2ce766a47d721fc71ccb9614a2bb85c47a14370bd636b202b770737d4baba96848213d80841cba
• Download URL:
  https://stacks.cdc.gov/view/cdc/216001/cdc_216001_DS1.pdf
• File Type:
  [PDF - 160.39 KB ]