Determinants of Arsenic Methylation Efficiency and Urinary Arsenic Level in Pregnant Women in Bangladesh

Details

• Personal Author:
  Christiani, David C. ; Coull B ; Gao S ; Hsueh Y-m ; Lin P-I ; Mostofa G ; Quamruzzaman Q ; Rahman M ; Rahman ML ; Su L ; Weisskopf M
• Description:
  BACKGROUND: Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic. METHODS: In a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4-16 weeks, and the second at 21-37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the difference in arsenic methylation using a paired t-test between first and second visits. Using linear regression, we examined determinants of arsenic metabolism, including age, BMI at enrollment, education, financial provider income, arsenic exposure level, and dietary folate and protein intake, adjusted for daily energy intake. RESULTS: Comparing visit 2 to visit 1, iAs% decreased 1.1% (p < 0.01), and creatinine-adjusted urinary arsenic level (U-As) increased 21% (95% CI: 15, 26%; p < 0.01). Drinking water arsenic concentration was positively associated with iAs% at both visits. When restricted to participants with higher adjusted urinary arsenic levels (adjusted U-As > 50 ug/g-creatinine) gestational age at measurement was strongly associated with DMA% (beta = 0.38, p < 0.01) only at visit 1. Additionally, DMA% was negatively associated with daily protein intake (beta = - 0.02, p < 0.01) at visit 1, adjusting for total energy intake and other covariates. CONCLUSIONS: Our findings indicate that arsenic metabolism and adjusted U-As level increase during pregnancy. We have identified determinants of arsenic methylation efficiency at visit 1. [Description provided by NIOSH]
• Subjects:
  Arsenic Energy Metabolism Environmental Exposure Hazardous Substances Inorganic Chemicals Occupational Health Pregnancy Risk Assessment Risk Factors Safety Urine Urogenital System Women

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• Keywords:
  Author Keywords: Arsenic Metabolism Environmental Arsenic Exposure Environmental Exposure Exposure Levels Humans Metabolism Prenatal Exposure Proteins Reproductive Health Risk Factors Toxins Urinalysis Urinary Arsenic Metabolites

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• ISSN:
  1476-069X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  94
• Volume:
  18
• Issue:
  1
• NIOSHTIC Number:
  nn:20057737
• Citation:
  Environ Health 2019 Nov; 18(1):94
• Contact Point Address:
  David Chistopher Christiani, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115
• Email:
  dchris@hsph.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2020
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health: A Global Access Science Source
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:157ca8430921306cd13b5d3a47ef6ddc2fafc0b8eb91e613c145f22108c2e4ccb75d46c3cf50491bcf1aa6ac37bc9f6e57b89722d73c300ec5b3674fc800b4cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/214977/cdc_214977_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]