Maternal Arsenic Exposure Associated with Low Birth Weight in Bangladesh

Details

• Personal Author:
  Afroz S ; Breton CV ; Christiani, David C. ; Dobson CB ; Frelich J ; Hoffman E ; Huyck KL ; Islam S ; Kile ML ; Mahiuddin G ; Quamruzzaman Q ; Rahman M ; Yousuf J
• Description:
  OBJECTIVE: To characterize the effects of maternal arsenic exposure on birth weight. METHODS: Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductively coupled plasma-mass spectrometry. The association between arsenic and birth weight was investigated using linear and logistic regression models. RESULTS: Maternal hair arsenic measured early in pregnancy was associated with decreased birth weight (beta = -193.5 +/- 90.0 g, P = 0.04). Maternal hair and drinking water arsenic levels measured at first prenatal visit were significantly correlated with newborn hair arsenic level (rho = 0.32, P = 0.04 and rho = 0.31, P = 0.04). CONCLUSIONS: Results suggest that maternal arsenic exposure early in pregnancy negatively affects newborn birth weight and that maternal hair provides the best integrated measure of arsenic exposure. [Description provided by NIOSH]
• Subjects:
  Arsenic Environmental Exposure Epidemiology Inorganic Chemicals Men Occupational Health Pregnancy Risk Assessment Risk Factors Safety Surveys And Questionnaires Women

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• Keywords:
  Environmental Exposure Exposure Levels Humans Mass Spectrometry Models Pharmacology Prenatal Exposure Questionnaires Risk Factors Sampling Weight Factors

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  49
• Issue:
  10
• NIOSHTIC Number:
  nn:20056936
• Citation:
  J Occup Environ Med 2007 Oct; 49(10):1097-1104
• Contact Point Address:
  David C. Christiani, MD, MPH, Department of Environmental Health, Harvard School of Public Health, Building 1, Room 1408, 665 Huntington Avenue, Boston, MA 02115
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba8795c08f3247ef50b79b64b4a6fa6157d5d0213c9a78e059fee1c9550d01fdfca0816c89d2c114a9cff2dd866454e909ef80c20de771416970fe9c2d51c563
• Download URL:
  https://stacks.cdc.gov/view/cdc/214427/cdc_214427_DS1.pdf
• File Type:
  [PDF - 186.39 KB ]