Selected Occupational Characteristics and Change in Leukocyte Telomere Length over 10 Years: The Multi-Ethnic Study of Atherosclerosis (MESA)

Details

• Personal Author:
  Diez Roux AV ; Fujishiro K ; Jenny NS ; Landsbergis PA ; Needham BL ; Seeman T
• Description:
  Telomere length (TL) is considered as a marker of cell senescence, but factors influencing the rate of TL attrition are not well understood. While one previous study reported the association of occupation and TL, many subsequent studies have failed to find the association. This may be due to heterogeneity within the samples and cross-sectional designs. This longitudinal study examines two occupational characteristics, occupational complexity and hazardous conditions, as predictors of TL attrition in gender- and race/ethnicity-stratified analysis. Leukocyte TL (expressed as T/S ratio) was measured twice over a 10-year period in a multi-racial sample (n = 914). Linear mixed effect models were used to estimate TL attrition associated with occupational complexity and hazardous conditions. Analysis was stratified by gender and race/ethnicity (white, African American, and Latino) and controlled for baseline age, baseline TL, and time since baseline. Higher occupational complexity was associated with slower rates of TL attrition only among white men. Hazardous conditions were not associated with TL attrition for any gender-and-race/ethnicity stratified group. Occupational complexity may influence TL attrition, but the different findings for white men and other groups suggest that a more comprehensive framework is needed to better understand the potential link between occupational characteristics and biological aging. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Chromosomes Demography Men Occupational Health Race Factors Safety Women Workplace
• Keywords:
  Biological Effects Cell Type Chromosome Damage Chromosome Disorders Demographic Characteristics Deoxyribonucleic Acids DNA DNA Damage Hazards Humans Job Analysis Leukocytes Longitudinal Study Mathematical Models Occupational Health Occupations Racial Factors Socioeconomics Statistical Analysis Work Analysis Work Environment Workers

  More +
• ISSN:
  1932-6203
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; New York ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  9
• NIOSHTIC Number:
  nn:20053142
• Citation:
  PLoS One 2018 Sep; 13(9):0204704
• Contact Point Address:
  Kaori Fujishiroa, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, United States of America
• Email:
  Kfujishiro@cdc.gov
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  PLoS One
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8b288f46c895c2a261d608d1150d1073542d3bad79645f5615385c2da79f66c9eb56c3d5b54bd1294326bbdff397e42a544cf50f596ad2d20657fa18ccdead8b
• Download URL:
  https://stacks.cdc.gov/view/cdc/215959/cdc_215959_DS1.pdf
• File Type:
  [PDF - 456.58 KB ]