Current employment status, occupational category, occupational hazard exposure and job stress in relation to telomere length: the Multiethnic Study of Atherosclerosis (MESA)

Details

• Personal Author:
  Diez-Roux AV ; Fujishiro K ; Jenny NS ; Landsbergis PA ; Seeman T
• Description:
  OBJECTIVE: Telomere length has been proposed as a biomarker of cell senescence, which is associated with a wide array of adverse health outcomes. While work is a major determinant of health, few studies have investigated the association of telomere length with various dimensions of occupation. Accelerated cellular aging could be a common pathway linking occupational exposure to several health outcomes. METHODS: Leukocyte telomere length was assessed using quantitative PCR in a community-based sample of 981 individuals (age: 45-84 years). Questionnaires were used to collect information on current employment status, current or main occupation before retirement and job strain. The Occupational Resource Network (O*NET) database was linked to the questionnaire data to create five exposure measures: physical activity on the job, physical hazard exposure, interpersonal stressors, job control and job demands. Linear regression was used to estimate associations of occupational characteristics with telomere lengths after adjustment for age, sex, race, socioeconomic position and several behavioural risk factors. RESULTS: There were no mean differences in telomere lengths across current employment status, occupational category, job strain categories or levels of most O*NET exposure measures. There was also no evidence that being in lower status occupational categories or being exposed to higher levels of adverse physical or psychosocial exposures accelerated the association between age and telomere shortening. CONCLUSIONS: Cellular aging as reflected by shorter telomeres does not appear to be an important pathway linking occupation to various health outcomes. [Description provided by NIOSH]
• Subjects:
  Age Factors Behavior Biomarkers Chromosomes Demography DNA Occupational Exposure Occupational Health Race Factors Safety Stress, Psychological Surveys And Questionnaires

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• Keywords:
  Age-factors Biological-effects Cell-alteration Cell-damage Cellular-function Cellular-structures Chromosome-damage Chromosome-disorders Demographic-characteristics DNA-damage Emotional-stress Employee-exposure Employee-health Employees Information-systems Job-analysis Job-stress Leukocytes Occupations Physical-stress Questionnaires Racial-factors Sociological-factors

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; New York ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 5 ; OSHA Region 9 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  70
• Issue:
  8
• NIOSHTIC Number:
  nn:20042667
• Citation:
  Occup Environ Med 2013 Aug; 70(8):552-560
• Contact Point Address:
  Dr Kaori Fujishiro, Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy (R-15), Cincinnati OH 45226, USA
• Email:
  kfujishiro@cdc.gov
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:af90cacc17f4638a548df513b2514b1d1ed3edca6d15f50d6a82a897798a0f37547ac1d63eeb2b56f176797693d81a790008ba73c1eaca52c4c919a2f53610aa
• Download URL:
  https://stacks.cdc.gov/view/cdc/194815/cdc_194815_DS1.pdf
• File Type:
  [PDF - 114.33 KB ]