Estimation of a safe level for occupational exposure to vinyl chloride using a benchmark dose method in central China

Details

• Personal Author:
  Brandt-Rauf PW ; Feng N-N ; Jiao J ; Li Y ; Sun S-Y ; Sun Y ; Tan H-S ; Wang Q ; Wang W ; Xia Z-L ; Yao W ; Zhang G-H ; Zhu Y
• Description:
  OBJECTIVES: The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCM-exposed workers in central China and validate the published results in Shanghai. METHODS: VCM-exposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis-block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure. RESULTS: The MN frequency in the VCM-exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCM-exposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose-response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL(10) was found to be 630.6, 670.2 and 273.7 mg-year for all VCM-exposed workers, males and females, respectively. CONCLUSIONS: These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Chromosomes Demography Epidemiology Hazardous Substances Men Occupational Health Safety Smokers Women Workplace

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• Keywords:
  Age-factors Analytical-processes Author Keywords: Benchmark Dose Chromosome-damage Chromosome Damage Demographic-characteristics Exposure-levels Humans Micronucleus Frequency Monomers Pollutants Pollution Smoking Statistical-analysis Toxins Vinyl Chloride Monomer Work-environment Workers

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• ISSN:
  1341-9145
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; Illinois ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  263-270
• Volume:
  54
• Issue:
  4
• NIOSHTIC Number:
  nn:20042992
• Citation:
  J Occup Health 2012 Apr; 54(4):263-270
• Contact Point Address:
  Zhao-lin Xia, Department of Occupational Health and Toxicology, school of Public Health, Fudan University, 138 Yixueyuan road, Shanghai, 200032, China
• Email:
  zlxia@shmu.edu.cn
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Journal of Occupational Health
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ffb14c5a99d558bbd4d6bfb5e3d6dad57b1a805e50d99bbc44de8daf442d502f4a521e96d1e3ef7488842044a344d95179e0972f2439071e1837fd0323102511
• Download URL:
  https://stacks.cdc.gov/view/cdc/195035/cdc_195035_DS1.pdf
• File Type:
  [PDF - 221.72 KB ]