Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011

Rashed, Shah M.; Azman, Andrew S.; Alam, Munirul; Li, Shan; Sack, David A.; Morris, J. Glenn; Longini, Ira; Siddique, Abul Kasem; Iqbal, Anwarul; Huq, Anwar; Colwell, Rita R.; Sack, R. Bradley; Stine, O. Colin

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Genetic Variation of Vibrio cholerae during Outbreaks, Bangladesh, 2010–2011

Supporting Files Public Domain

Jan 2014
By Rashed, Shah M. ; Azman, Andrew S. ; Alam, Munirul

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Rashed, Shah M. ; Azman, Andrew S. ; Alam, Munirul ; Li, Shan ; Sack, David A. ; Morris, J. Glenn ; Longini, Ira ; Siddique, Abul Kasem ; Iqbal, Anwarul ; Huq, Anwar ; Colwell, Rita R. ; Sack, R. Bradley ; Stine, O. Colin
Description:

Cholera remains a major public health problem. To compare the relative contribution of strains from the environment with strains isolated from patients during outbreaks, we performed multilocus variable tandem repeat analyses on samples collected during the 2010 and 2011 outbreak seasons in 2 geographically distinct areas of Bangladesh. A total of 222 environmental and clinical isolates of V. cholerae O1 were systematically collected from Chhatak and Mathbaria. In Chhatak, 75 of 79 isolates were from the same clonal complex, in which extensive differentiation was found in a temporally consistent pattern of successive mutations at single loci. A total of 59 isolates were collected from 6 persons; most isolates from 1 person differed by sequential single-locus mutations. In Mathbaria, 60 of 84 isolates represented 2 separate clonal complexes. The small number of genetic lineages in isolates from patients, compared with those from the environment, is consistent with accelerated transmission of some strains among humans during an outbreak.
Subjects:
Source:

Emerg Infect Dis. 20(1):54-60.
Document Type:

Journal Article
Place as Subject:

Bangladesh
Location:

Asia
Volume:

20
Issue:

1
Download URL:

https://stacks.cdc.gov/view/cdc/21523/cdc_21523_DS1.pdf
File Type:

[PDF - 488.00 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d91f27995ca41a1bc907d5764d3400d16eb2bb3923934318db08a2dd262cf18a

File Language:

English

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