Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

Freiesleben de Blasio, Birgitte; Flem, Elmira; Latipov, Renat; Kuatbaeva, Ajnagul; Kristiansen, Ivar Sønbø

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Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

Published Date:

Jan 2014

Source:

Emerg Infect Dis. 20(1):29-37.

[PDF-501.07 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Freiesleben de Blasio, Birgitte ; Flem, Elmira ; Latipov, Renat ; Kuatbaeva, Ajnagul ; Kristiansen, Ivar Sønbø ;

Description:

The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost at

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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