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Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan
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Published Date:
Jan 2014
Source:Emerg Infect Dis. 20(1):29-37.
[PDF-501.07 KB]
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost atSubject:Document Type:Collection(s):Main Document Checksum:File Type:
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