Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Freiesleben de Blasio, Birgitte ; Flem, Elmira ; Latipov, Renat ; Kuatbaeva, Ajnagul ; Kristiansen, Ivar Sønbø
• Description:
  The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost at
• Subjects:
  Adolescent Adult Child Child, Preschool Cost-Benefit Analysis Humans Immunization Programs Incidence Infant Infant, Newborn Middle Aged Rotavirus Rotavirus Infections Rotavirus Vaccines Vaccination Young Adult

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• Source:
  Emerg Infect Dis. 20(1):29-37.
• Document Type:
  Journal Article
• Place as Subject:
  Kazakhstan
• Volume:
  20
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2847ab34bfe6d2d7191c082800a69133fcd08c8d653cbe07c67bb3e58e7e2d43
• Download URL:
  https://stacks.cdc.gov/view/cdc/21515/cdc_21515_DS1.pdf
• File Type:
  [PDF - 501.07 KB ]