Circulating Estradiol in Men Is Inversely Related to Urinary Metabolites of Nonpersistent Insecticides

Details

• Personal Author:
  Barr DB ; Hauser R ; Meeker JD ; Ravi SR
• Description:
  Background: Estradiol plays an important role in male reproductive health as a germ cell survival factor. Chlorpyrifos and carbaryl, nonpersistent insecticides to which the general population are commonly exposed, were recently shown to inhibit estradiol metabolism in vitro which could lead to altered hormone balance. Methods: Subjects (N=322) were the male partners in couples presenting to a Massachusetts infertility clinic from years 2000-2003. 3,5,6-trichloro-2-pyridinol (TCPY), the major urinary metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1- and 2-naphthol (1N and 2N), urinary metabolites of carbaryl and naphthalene, were measured in a spot urine sample from each subject. Estradiol, sex hormone binding globulin, and prolactin were measured in serum collected from subjects during the same clinic visit. Results: Using multiple linear regression, an interquartile range increase in TCPY was associated with a 1.36 pg/mL decline (95% confidence interval = -2.91 to -0.22) in estradiol concentration. When estradiol and TCPY were divided into quintiles, there was a dose-dependent increase in the odds of being in the lowest estradiol quintile with increasing TCPY quintiles. Conclusion: On a population level, these reductions in estradiol levels are of potential public health importance because of widespread exposure to TCPY and its parent insecticides. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Insecticides Men Occupational Health Safety Urine Urogenital System
• Keywords:
  Author Keywords: Carbaryl Carbaryl Chlorpyrifos Endocrine Disruption Estradiol Fertility Hormone Humans Infertility Male Reproduction Metabolism Metabolites Naphthalene Pesticides Prolactin Reproductive Effects Reproductive Health Sampling Urinalysis Urine Chemistry

  More +
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  184-191
• Volume:
  25
• Issue:
  2
• NIOSHTIC Number:
  nn:20057804
• Citation:
  Reprod Toxicol 2008 Feb; 25(2):184-191
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan, School of Public Health, 6635 SPH Tower, 109 South Observatory Street, Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  2-Naphthol (CAS RN 135-19-3) ; 3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Carbaryl (CAS RN 63-25-2) ; Chlorpyrifos (CAS RN 2921-88-2) ; Naphthalene (CAS RN 91-20-3)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5c458e539ba3ea54cf0dec41c8439a6d6b1b107ae1a7c16b6076ae5ed46de921176a360e7168b07f067e834395f104020dcb31cf8edcbe993729843108e4a44c
• Download URL:
  https://stacks.cdc.gov/view/cdc/215029/cdc_215029_DS1.pdf
• File Type:
  [PDF - 283.14 KB ]