Temporal Variability of Urinary Levels of Nonpersistent Insecticides in Adult Men

Details

• Personal Author:
  Barr DB ; Bennett DH ; Bravo R ; Hauser R ; Herrick, Robert F. ; Meeker JD ; Ryan L
• Description:
  Widespread application of contemporary-use insecticides results in low-level exposure for a majority of the population through a variety of pathways. Urinary insecticide biomarkers account for all exposure pathways, but failure to account for temporal within-subject variability of urinary levels can lead to exposure misclassification. To examine temporal variability in urinary markers of contemporary-use insecticides, nine repeated urine samples were collected over 3 months from 10 men participating in an ongoing study of male reproductive health. These 90 samples were analyzed for urinary metabolites of chlorpyrifos (3,5,6-trichloro-2-pyridinol (TCPY)) and carbaryl (1-naphthol (1N)). Volume- based (unadjusted), as well as creatinine (CRE)- and specific gravity (SG)-adjusted concentrations were measured. TCPY had low reliability with an intraclass correlation coefficient between 0.15 and 0.21, while 1N was moderately reliable with an intraclass correlation coefficient between 0.55 and 0.61. When the 10 men were divided into tertiles based on 3-month geometric mean TCPY and 1N levels, a single urine sample performed adequately in classifying a subject into the highest or lowest exposure tertiles. Sensitivity and specificity ranged from 0.44 to 0.84 for TCPYand from 0.56 to 0.89 for 1N. Some differences in the results between unadjusted metabolite concentrations and concentrations adjusted for CRE and SG were observed. Questionnaires were used to assess diet in the 24 h preceding the collection of each urine sample. In mixed-effects models, TCPY was significantly associated with season as well as with consuming grapes and cheese, while 1N levels were associated with consuming strawberries. In conclusion, although a single sample adequately predicted longer-term average exposure, a second sample collected at least 1 month following the first sample would reduce exposure measurement error. [Description provided by NIOSH]
• Subjects:
  Biomarkers Diet Energy Metabolism Environmental Exposure Insecticides Men Occupational Health Risk Assessment Risk Factors Safety Surveys And Questionnaires Urine Urogenital System

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• Keywords:
  Author Keywords: Biomonitoring Biomonitoring Carbaryl Chlorpyrifos Exposure Assessment Exposure Levels Humans Measurement Error Metabolites Models Pesticides Questionnaires Reproductive Health Risk Factors Urine Chemistry

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• ISSN:
  1053-4245
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  271-281
• Volume:
  15
• Issue:
  3
• NIOSHTIC Number:
  nn:20057776
• Citation:
  J Expo Anal Environ Epidemiol 2005 May; 15(3):271-281
• Contact Point Address:
  Dr. R Hauser, Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Building 1 Room 1405, 665 Huntington Avenue, Boston, MA 02115
• Email:
  rhauser@hohp.harvard.edu
• CAS Registry Number:
  3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Carbaryl (CAS RN 63-25-2) ; Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Journal of Exposure Analysis and Environmental Epidemiology
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d42fb803db67ee793e5e1dfe3aa07a9acc05cd9fbe5dc4f2e57e3ac9b9e77a5eca4abef00d9569f4643bf2ebabcf865eed30061ffb0b67bda7605c1779dc1213
• Download URL:
  https://stacks.cdc.gov/view/cdc/215009/cdc_215009_DS1.pdf
• File Type:
  [PDF - 216.85 KB ]