Novel QUEST MRI In Vivo Measurement of Noise-Induced Oxidative Stress in the Cochlea

Details

• Personal Author:
  Apawu AK ; Berkowitz BA ; Braun RD ; Dixon A ; Hali M ; Holt AG ; Kühl A ; Muca A ; Sinan M ; Warila J
• Description:
  Effective personalized therapeutic treatment for hearing loss is currently not available. Cochlear oxidative stress is commonly identified in the pathogenesis of hearing loss based upon findings from excised tissue, thus suggesting a promising druggable etiology. However, the timing and site(s) to target for anti-oxidant treatment in vivo are not clear. Here, we address this long-standing problem with QUEnch-assiSTed Magnetic Resonance Imaging (QUEST MRI), which non-invasively measures excessive production of free radicals without an exogenous contrast agent. QUEST MRI is hypothesized to be sensitive to noise-evoked cochlear oxidative stress in vivo. Rats exposed to a loud noise event that resulted in hair cell loss and reduced hearing capability had a supra-normal MRI R1 value in their cochleae that could be corrected with anti-oxidants, thus non-invasively indicating cochlear oxidative stress. A gold-standard oxidative damage biomarker [heme oxidase 1 (HO-1)] supported the QUEST MRI result. The results from this study highlight QUEST MRI as a potentially transformative measurement of cochlear oxidative stress in vivo that can be used as a biomarker for improving individual evaluation of anti-oxidant treatment efficacy in currently incurable oxidative stress-based forms of hearing loss. [Description provided by NIOSH]
• Subjects:
  Antioxidants Biomarkers Diagnosis Ear Free Radicals Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Noise, Occupational Occupational Health Safety Sense Organs

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• Keywords:
  Diagnostic Techniques Ears Free Radicals Hearing Loss In Vivo Study Laboratory Animals Magnetic Resonance Imaging Medical Treatment MRI Noise Exposure Noise Induced Hearing Loss Oxidative Stress Pathogenesis Therapeutic Agents

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• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• NIOSHTIC Number:
  nn:20057752
• Citation:
  Sci Rep 2019 Nov; 9:16265
• Contact Point Address:
  Avril Genene Holt, Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA
• Email:
  agholt@med.wayne.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Scientific Reports
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5d509f00aa1f464750ad92abc865f1e928ca707646b8c8765db4e90c1c261c73f5c2c7fdbb567fd22c77b9527b7590719846c4aee0df0eabf9b7cfd8c405b331
• Download URL:
  https://stacks.cdc.gov/view/cdc/214989/cdc_214989_DS1.pdf
• File Type:
  [PDF - 1.42 MB ]