Models for Assessing Risk of Occupational Hearing Loss

Details

• Personal Author:
  Fechter LD
• Description:
  The research undertaken under this grant was designed to determine the ability of the chemical asphyxiants, carbon monoxide and cyanide, to potentiate noise induced hearing loss. Such mixed exposure to noise and asphyxiant can be predicted to occur in a number or workplace settings such as those that firefighters and truck drivers experience. The results of experiments conducted in rats demonstrate that these asphyxiants do potentiate noise induced hearing loss in a concentration dependent fashion and with an estimated lower bound benchmark concentration of approximately 200-300ppm. Asphyxiants may also increase vulnerability under conditions of intermittent noise exposure. A probable mechanism responsible for potentiation of noise induced hearing loss by asphyxiants is enhancement of free radical species with subsequent tissue damage. [Description provided by NIOSH]
• Subjects:
  Chemistry Free Radicals Hearing Loss Hearing Loss, Noise-Induced Noise Noise, Occupational Occupational Health Safety
• Keywords:
  Chemical Reactions Free Radical Generation Free Radicals Hearing Loss Noise Exposure Noise Induced Hearing Loss Ototoxicity Tissue Disorders
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Oklahoma ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:20023718
• NTIS Accession Number:
  PB2004-104023
• Citation:
  NIOSH 2000 Nov; :1-9
• Contact Point Address:
  University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, P.O. Box 26901, Oklahoma City, OK 73190
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0) ; Hydrogen cyanide (CAS RN 74-90-8)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Hearing Loss
• Performing Organization:
  University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
• Peer Reviewed:
  False
• Start Date:
  19970901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20000831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a5a54b3d4c48e78f8a503f5fb204216bb5bba85427ab73de02514d2a28ccb80dde042b900c0c0cc658817f0b75eb8964b9145bd294f31f8e80ed90788d0424a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/218079/cdc_218079_DS1.pdf
• File Type:
  [PDF - 857.29 KB ]