Involvement of Oxidative Stress in Potentiation of Noise Induced Hearing Loss (NIHL) by Chemical Contaminants

Details

• Personal Author:
  Fechter LD ; Gearhart CA ; Pouyatos B
• Description:
  Permissible workplace exposure limits for noise and for chemical contaminants generally rely upon laboratory and epidemiological investigations that entail exposure to the single agent of interest. However, a growing body of research shows that a variety of chemical contaminants, including those that have no effect upon auditory function, can potentiate noise induced hearing loss. Such potentiation is particularly noteworthy when it occurs for low intensity noise exposures that approach the permissible human noise exposure standards.We predict that chemicals able to impair intrinsic antioxidant mechanisms potentiate NIHL since reactive oxygen species may be generated even at low noise levels. Combined exposure of rats to hydrogen cyanide and mild noise yields significant auditory impairment while at neither agent given alone resulted in hearing loss. Using antioxidant drug treatments to protect auditory function and pro-oxidant drugs to promote oxidative stress we find support for our hypothesis that oxidative stress does play a role in potentiation of noise induced hearing loss by hydrogen cyanide. [Description provided by NIOSH]
• Subjects:
  Chemistry Free Radicals Hearing Loss Hearing Loss, Noise-Induced Noise Noise, Occupational Occupational Health Safety
• Keywords:
  Chemical Reactions Free Radical Generation Free Radicals Hearing Loss Noise Exposure Noise Induced Hearing Loss Ototoxicity Synergism Tissue Disorders
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Oklahoma ; OSHA Region 6 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10
• Volume:
  84
• NIOSHTIC Number:
  nn:20026425
• Citation:
  Toxicologist 2005 Mar; 84(Suppl 1):10
• CAS Registry Number:
  Hydrogen cyanide (CAS RN 74-90-8)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Hearing Loss
• Performing Organization:
  University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
• Peer Reviewed:
  False
• Start Date:
  19970901
• Source Full Name:
  The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
• Supplement:
  1
• End Date:
  20000831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2e159aee9cf59fed0f0cc59b263e1d0bdbdb9b028ee52b38d6a395616808d1eb6b4585c8dd34146ea6aaeba53a3f24a62ba241e35da6484132039413db7aae8
• Download URL:
  https://stacks.cdc.gov/view/cdc/197276/cdc_197276_DS1.pdf
• File Type:
  [PDF - 327.41 KB ]