The Impact of Diet and Betel Nut Use on Skin Lesions Associated with Drinking-Water Arsenic in Pabna, Bangladesh

Details

• Personal Author:
  Christiani, David C. ; Houseman EA ; Mahiuddin G ; McCarty KM ; Quamruzzaman Q ; Rahman M ; Ryan L ; Smith T
• Description:
  An established exposure-response relationship exists between water arsenic levels and skin lesions. Results of previous studies with limited historical exposure data, and laboratory animal studies suggest that diet may modify arsenic metabolism and toxicity. In this study, we evaluated the effect of diet on the risk of arsenic-related skin lesions in Pabna, Bangladesh. Six hundred cases and 600 controls loosely matched on age and sex were enrolled at Dhaka Community Hospital, Bangladesh, in 2001-2002. Diet, demographic data, and water samples were collected. Water samples were analyzed for arsenic using inductively coupled plasma mass spectroscopy. Betel nut use was associated with a greater risk of skin lesions in a multivariate model [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.18-2.36]. Modest decreases in risk of skin lesions were associated with fruit intake 1-3 times/month (OR = 0.68; 95%CI, 0.51-0.89) and canned goods at least 1 time/month (OR = 0.41; 95% CI, 0.20-0.86). Bean intake at least 1 time/day (OR = 1.89; 95% CI, 1.11-3.22) was associated with increased odds of skin lesions. Betel nut use appears to be associated with increased risk of developing skin lesions in Bangladesh. Increased intake of fruit and canned goods may be associated with reduced risk of lesions. Increased intake of beans may be associated with an increased risk of skin lesions. The results of this study do not provide clear support for a protective effect of vegetable and overall protein consumption against the development of skin lesions, but a modest benefit cannot be excluded. [Description provided by NIOSH]
• Subjects:
  Aging Animals Arsenic Demography Diet Energy Metabolism Environmental Exposure Hazardous Substances Inorganic Chemicals Laboratories Men Occupational Health Risk Assessment Risk Factors Safety Skin Women

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• Keywords:
  Age Groups Author Keywords: Arsenic Bangladesh Betel Nut Case-control Demographic Characteristics Exposure Levels Humans Laboratory Animals Mass Spectrometry Metabolism Models Risk Factors Sampling Skin Exposure Skin Lesions Statistical Analysis Toxins Water Sampling

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  334-340
• Volume:
  114
• Issue:
  3
• NIOSHTIC Number:
  nn:20057651
• Citation:
  Environ Health Perspect 2006 Mar; 114(3):334-340
• Contact Point Address:
  D.C. Christiani, Department of Environmental Health, Harvard School of Public Health, Building I 1408, 665 Huntington Ave., Boston, MA 02115
• Email:
  dchristi@hsph.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2006
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0ad2a94b87afd74682d8ff6b78d61f7d8c07a0bf2cb61e5b7eaa95c1b7e0ab52339bb8f88b8a21886a3ec73c4f7edba6f40bb1ed286d8c8873de2b82d4adac7
• Download URL:
  https://stacks.cdc.gov/view/cdc/214922/cdc_214922_DS1.pdf
• File Type:
  [PDF - 132.09 KB ]