Dietary Arsenic Exposure in Bangladesh

Details

• Personal Author:
  Breton CV ; Christiani, David C. ; Houseman EA ; Kile ML ; Mahiuddin G ; Quamruzzaman Q ; Rahman M ; Smith T
• Description:
  BACKGROUND: Millions of people in Bangladesh are at risk of chronic arsenic toxicity from drinking contaminated groundwater, but little is known about diet as an additional source of As exposure. METHODS: We employed a duplicate diet survey to quantify daily As intake in 47 women residing in Pabna, Bangladesh. All samples were analyzed for total As, and a subset of 35 samples were measured for inorganic arsenic (iAs) using inductively coupled plasma mass spectrometry equipped with a dynamic reaction cell. RESULTS: Median daily total As intake was 48 microg As/day [interquartile range (IQR), 33-67) from food and 4 microg As/day (IQR, 2-152) from drinking water. On average, iAs comprised 82% of the total As detected in dietary samples. After adjusting for the estimated inorganic fraction, 34% [95% confidence interval (CI), 21-49%] of all participants exceeded the World Health Organization's provisional tolerable daily intake (PTDI) of 2.1 microg As/kg-day. Two of the 33 women who used a well with < 50 microg As/L exceeded this recommendation. CONCLUSIONS: When drinking water concentrations exceeded the Bangladesh drinking water standard of 50 microg As/L, ingested water was the dominant source of exposure. However, as drinking water As concentrations decrease, the relative contribution of dietary As sources becomes more important to ingested dose. The combined intake from both diet and drinking water can cause some individuals to exceed the PTDI in spite of using a tube well that contains < 50 microg As/L. [Description provided by NIOSH]
• Subjects:
  Arsenic Biomarkers Diet Environmental Exposure Inorganic Chemicals Occupational Health Risk Assessment Risk Factors Safety Women
• Keywords:
  Arsenic Compounds Author Keywords: Arsenic Bangladesh Dose Duplicate Diet Exposure Levels Food Humans Inorganic Compounds Intake Mass Spectrometry Risk Factors Sampling Statistical Analysis Water Water Supply

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  115
• Issue:
  6
• NIOSHTIC Number:
  nn:20057291
• Citation:
  Environ Health Perspect 2007 Jun; 115(6):889-893
• Contact Point Address:
  M. Kile, Harvard School of Public Health, Building 1, Room 1408, 677 Huntington Ave., Boston, MA 02115
• Email:
  mkile@hsph.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a28f71143ff1cf43af59e1819a43c2b111a088395338ab90e10e10395d89ff313a68e18c0ff5c2d64f8b932d6dce40b30d4b0abea29b238cf4175ec6d25ab0d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/214689/cdc_214689_DS1.pdf
• File Type:
  [PDF - 138.99 KB ]