Styrene, Styrene-7,8-Oxide, and Quinoline

Details

• Personal Author:
  Bertke SJ ; Calaf GM ; Colosio C ; Fritz JM ; Fukushima S ; Gwinn WM ; Hemminki K ; Jensen AA ; Kogevinas M ; Kolstad H ; Kriebel D ; Mráz J ; Nesnow S ; Nylander-French L ; Parent M-E ; Phillips DH ; Sandy M ; Sim M ; Smith-Roe SL ; Stoner G ; Suzuki T ; Teixeira JP ; Vodicka P
• Description:
  This volume of the IARC Monographs provides evaluations of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide. Quinoline and styrene are present in air pollution and in tobacco smoke. Quinoline also occurs in the processing of petroleum and shale oil, and is found in groundwater and soil at sites contaminated by coal tar and creosote. Quinoline and styrene are high production volume chemicals. Quinoline is used to produce various drugs and dyes. Styrene is primarily used in the production of polystyrene polymers. Styrene-7,8-oxide is primarily used to produce epoxy resins. Styrene-7,8-oxide is the primary metabolite of styrene in humans. Styrene and styrene-7,8-oxide are found in workplace air, particularly in the reinforced plastics industry and the rubber industry. Exposure to these agents may occur in the general population as well as in various occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents. [Description provided by NIOSH]
• Subjects:
  Acids Air Pollutants, Occupational Animals Biological Assay Biomarkers Carcinogens Chemistry Coloring Agents Epidemiology Hazardous Substances Laboratories Neoplasms Occupational Health Petroleum Phenol Polymers Safety Smoke Styrene Tobacco Products Toxicology

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• Keywords:
  Air Pollutants Animal Studies Bioassays Biological Agents Biological Effects Cancer Carcinogenicity Chemical Agents Chemical Analysis Coal Tar Cresols Data Processing Drugs Dyes Epoxy Resins Exposure Assessment Health Hazards Humans Laboratory Animals Medical Research Oil Shale Organic Compounds Oxides Phenols Quinolines Reinforced Plastics Rubber Manufacturing Industry Styrene Butadiene Resins Styrene Resins Styrenes Tobacco Smoke Wood Tar Creosote

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• ISBN:
  9789283201885
• ISSN:
  1017-1606
• Publisher:
  International Agency for Research on Cancer
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  California ; District of Columbia ; Massachusetts ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-345
• Volume:
  121
• NIOSHTIC Number:
  nn:20057390
• Citation:
  IARC monographs on the evaluation of carcinogenic risks to humans. Lyon, France: International Agency for Research on Cancer, 2019 Sep; 121:1-345
• CAS Registry Number:
  Mandelic acid (CAS RN 90-64-2) ; Phenylglyoxylic acid (CAS RN 611-73-4) ; Polystyrene (CAS RN 9003-53-6) ; Quinoline (CAS RN 91-22-5) ; Styrene (CAS RN 100-42-5) ; Styrene oxide (CAS RN 96-09-3)
• Editor(s):
  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  False
• Source Full Name:
  IARC monographs on the evaluation of carcinogenic risks to humans
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:20be43f36d8dc47f099d3d10badd400c8b72312312c235113cef8dbc739a6b4381d986cc0aee5cb3f04e8ab5d85e90ba212a149f3c66daa377d3d7ae26167de7
• Download URL:
  https://stacks.cdc.gov/view/cdc/214750/cdc_214750_DS1.pdf
• File Type:
  [PDF - 6.38 MB ]