Carcinogenicity of Quinoline, Styrene, and Styrene-7,8-Oxide

Details

• Personal Author:
  Benbrahim-Tallaa L ; Bertke SJ ; Bouvard V ; Calaf GM ; Colosio C ; Driscoll T ; El Ghissassi F ; Fritz JM ; Fukushima S ; Grosse Y ; Guha N ; Guyton KZ ; Gwinn WG ; Hall A ; Hemminki K ; Jaillet C ; Jensen AA ; Kogevinas M ; Kolstad H ; Kriebel D ; Mattock H ; Middleton D ; Mráz J ; Nesnow S ; Nylander-French LA ; Parent M-E ; Paulo Teixeira J ; Phillips DH ; Sandy M ; Sim M ; Smith-Roe SL ; Stoner G ; Straif K ; Suzuki T ; Tornero-Velez R ; Vilahur N ; Vodicka P
• Description:
  In March, 2018, a Working Group of 23 scientists from 12 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide. This assessment will be published in Volume 121 of the IARC Monographs. Quinoline is an azaarene that is present in tobacco smoke and air pollution. Quinoline occurs in petroleum and shale oil processing, and is found in groundwater and soil at coal tar and creosote-contaminated sites. A high production volume chemical, quinoline is used to produce a variety of drugs and dyes. No data were available on cancer in humans, or on exposure, absorption, or distribution of quinoline in humans. In mice and rats, quinoline induced rare tumours of various embryological origins. Malignant tumours were induced with a high incidence at the lowest dose tested, occurred with short latency, and caused early deaths. In both sexes of Crj:BDF1 mice, drinking water exposure to quinoline increased the incidences of liver histiocytic sarcoma, and in various organs, haemangioma and haemangiosarcoma. Additionally, hepatocellular carcinoma incidence was increased in male mice. Quinoline administered by intraperitoneal injection in CD-1 mice induced lymphoma in females and hepatocellular carcinoma in males. In male and female F344/DuCrj rats, drinking water containing quinoline increased the incidences of haemangiosarcoma (in various organs), and hepatocellular adenoma and carcinoma. Nasal cavity sarcoma, nasal esthesioneuroepithelioma, and mediastinal sarcoma were increased in male rats. In three feeding studies, quinoline increased the incidence of liver haemangiosarcoma in male rats of various strains. There was strong evidence that quinoline is genotoxic in experimental systems, inducing mutations and chromosomal damage in rodents and in vitro (upon metabolic activation), but no human data on cancer mechanisms were available. The Working Group classified quinoline as "possibly carcinogenic to humans", Group 2B, based on sufficient evidence of carcinogenicity in experimental animals. [Description provided by NIOSH]
• Subjects:
  Animals Blood Carcinogens Chemistry Chromosomes Embryology Epidemiology Laboratories Neoplasms Occupational Health Safety Styrene

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• Keywords:
  Animal Studies Biological Effects Blood Vessels Cancer Carcinogenicity Carcinomas Cellular Effects Chemical Analysis Chromosome Damage Connective Tissue Exposure Assessment Feeding Study Genotoxic Effects Heterocyclic Compounds Laboratory Animals Liver Cancer Liver Cells Lymphatic Cancer Malignancy Medical Research Metabolic Activation Mutation Nasal Cancer Olfactory Disorders Organonitrogen Compounds Organs Oxides Quinolines Sarcomagenicity Thorax Tumorigenesis Tumors

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• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  6
• NIOSHTIC Number:
  nn:20055228
• Citation:
  Lancet Oncol 2018 Jun; 19(6):728-729
• Contact Point Address:
  International Agency for Research on Cancer Monograph Working Group, International Agency for Research on Cancer, Lyon, France
• CAS Registry Number:
  Quinoline (CAS RN 91-22-5) ; Styrene (CAS RN 100-42-5) ; Styrene oxide (CAS RN 96-09-3)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  False
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7380e490aba81afae75f37512c7b8fe567d2d9e972c5e98e832e9307e75b79be22f857ee38b53171189ad00156c549c1095a0f059f2f045583a55a3198735ef0
• Download URL:
  https://stacks.cdc.gov/view/cdc/217576/cdc_217576_DS1.pdf
• File Type:
  [PDF - 45.61 KB ]