NaCl Nanoparticles as a Cancer Therapeutic

Details

• Personal Author:
  Avci FY ; Butler M ; Chen H ; Fu W ; Jiang W ; Li Z ; Paschall AV ; Shen Y ; Todd T ; Wang X ; Xie J ; Yao L ; Yin A ; Yin H ; Yin L ; Yu KS ; Yu X ; Zhang F ; Zhang L ; Zhang W ; Zhen Z ; Zhou S
• Description:
  Many inorganic nanoparticles are prepared and their behaviors in living systems are investigated. Yet, common electrolytes such as NaCl are left out of this campaign. The underlying assumption is that electrolyte nanoparticles will quickly dissolve in water and behave similarly as their constituent salts. Herein, this preconception is challenged. The study shows that NaCl nanoparticles (SCNPs) but not salts are highly toxic to cancer cells. This is because SCNPs enter cells through endocytosis, bypassing cell regulations on ion transport. When dissolved inside cancer cells, SCNPs cause a surge of osmolarity and rapid cell lysis. Interestingly, normal cells are much more resistant to the treatment due to their relatively low sodium levels. Unlike conventional chemotherapeutics, SCNPs cause immunogenic cell death or ICD. In vivo studies show that SCNPs not only kill cancer cells, but also boost an anticancer immunity. The discovery opens up a new perspective on nanoparticle-based therapeutics. [Description provided by NIOSH]
• Subjects:
  Behavior Hazardous Substances Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Apoptosis Cancer Cell Function Chemotherapy Electrolytes Immunogenic Cell Death Inorganic Compounds In Vivo Study Nanoparticles Nanotechnology Osmosis Therapeutic Agents Toxins

  More +
• ISSN:
  0935-9648
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  31
• Issue:
  46
• NIOSHTIC Number:
  nn:20057306
• Citation:
  Adv Mater 2019 Nov; 31(46):1904058
• Contact Point Address:
  Prof. Jin Xie, Department of Chemistry, University of Georgia Athens, GA 30602, USA
• Email:
  jinxie@uga.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Georgia, Athens
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Advanced Materials
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e0d9910a619eddcd157c9ac415b8d527aeeaa5418aae851b2000acbbc986f81bd6176344b4bef2372cbdabfc547b1fcc0effa32a407b002764f7dd1694f447d
• Download URL:
  https://stacks.cdc.gov/view/cdc/214701/cdc_214701_DS1.pdf
• File Type:
  [PDF - 8.23 MB ]