Digitoxin and its analogs as novel cancer therapeutics

Details

• Personal Author:
  Dinu C-Z ; Elbaz HA ; Rojanasakul Y ; Stueckle, Todd A. ; Tse W
• Description:
  A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs. [Description provided by NIOSH]
• Subjects:
  Chemistry Neoplasms Occupational Health Safety
• Keywords:
  Cancer Cell-function Cellular-function Chemical-composition Chemical-properties Chemotherapy Drugs Therapeutic-agents
• ISSN:
  2162-3619
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  4
• Volume:
  1
• Issue:
  1
• NIOSHTIC Number:
  nn:20046398
• Citation:
  Exp Hematol Oncol 2012 Apr; 1(1):4
• Email:
  yrojan@hsc.wvu.edu
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Experimental Hematology & Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16304d0c978a6ba9003f063f800a2c6a79e535a583191ce4faa8e8300f14fe795c61d9a7e155f3f5da76e7a26c4fd80c4d316820b23f1f9ea0ceec1a326dac2a
• Download URL:
  https://stacks.cdc.gov/view/cdc/201469/cdc_201469_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]