NaCl nanoparticles as a cancer therapeutic

Details

• Alternative Title:
  Adv Mater
• Personal Author:
  Jiang, Wen ; Yin, Lei ; Chen, Hongmin ; Paschall, Amy Victoria ; Zhang, Liuyang ; Fu, Wenyan ; Zhang, Weizhong ; Todd, Trever ; Yu, Kevin Shengyang ; Zhou, Shiyi ; Zhen, Zipeng ; Bultler, Michael ; Yao, Li ; Zhang, Feng ; Shen, Ye ; Li, Zibo ; Yin, Amelia ; Yin, Hang ; Wang, Xianqiao ; Avci, Fikri ; Yu, Xiaozhong ; Xie, Jin
• Description:
  Many inorganic nanoparticles are prepared and their behaviors in living systems are investigated. Yet, common electrolytes such as NaCl are left out of this campaign. The underlying assumption is that electrolyte nanoparticles will quickly dissolve in water and behave similarly as their constituent salts. Herein, this preconception is challenged. The study shows that NaCl nanoparticles (SCNPs) but not salts are highly toxic to cancer cells. This is because SCNPs enter cells through endocytosis, bypassing cell regulations on ion transport. When dissolved inside cancer cells, SCNPs cause a surge of osmolarity and rapid cell lysis. Interestingly, normal cells are much more resistant to the treatment due to their relatively low sodium levels. Unlike conventional chemotherapeutics, SCNPs cause immunogenic cell death or ICD. In vivo studies show that SCNPs not only kill cancer cells, but also boost an anticancer immunity. The discovery opens up a new perspective on nanoparticle-based therapeutics.
• Subjects:
  Cell Line, Tumor Endocytosis Humans Nanoparticles Neoplasms Sodium Chloride Theranostic Nanomedicine
• Keywords:
  Apoptosis Buprenorphine Cancer Immunogenic Cell Death Methadone Mortality Naltrexone Nanoparticles Osmosis Treatment
• Source:
  Adv Mater. 31(46):e1904058
• Pubmed ID:
  31553099
• Pubmed Central ID:
  PMC6886716
• Document Type:
  Journal Article
• Funding:
  R01EB022596/EB/NIBIB NIH HHSUnited States/ ; R01NS093314/HL/NHLBI NIH HHSUnited States/ ; R01 AR070178/AR/NIAMS NIH HHSUnited States/ ; R21 OH010473/OH/NIOSH CDC HHSUnited States/ ; R21OH010473/OH/NIOSH CDC HHSUnited States/ ; R01 AI123383/AI/NIAID NIH HHSUnited States/ ; R43ES027374/ES/NIEHS NIH HHSUnited States/ ; R01 NS093314/NS/NINDS NIH HHSUnited States/ ; R43 ES027374/ES/NIEHS NIH HHSUnited States/ ; R01 EB022596/EB/NIBIB NIH HHSUnited States/ ; R44 ES027374/ES/NIEHS NIH HHSUnited States/ ; R01AR070178/AR/NIAMS NIH HHSUnited States/
• Volume:
  31
• Issue:
  46
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4155fa7767f17a235976df0043f3c85b2cfc9902fb2034a05351dff0b6198f92f5d3fef63622c2161c763434a0ea2c5a8796d28dece34e6622e05c144febc2c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/83052/cdc_83052_DS1.pdf
• File Type:
  [PDF - 2.44 MB ]