Evidence-Based Guideline: Treatment of Painful Diabetic Neuropathy – Report of the American Association of Neuromuscular and Electrodiagnostic Medicine, the American Academy of Neurology, and the American Academy of Physical Medicine & Rehabilitatio

Details

• Personal Author:
  Backonja M ; Bril V ; Cohen JA ; Del Toro DR ; England JD ; Feldman EL ; Franklin GM ; Iverson DJ ; Perkins B ; Russell JW ; Zochodne DW
• Description:
  The objective of this report was to develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was: "What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; non-pharmacological: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?" A systematic review of literature from 1960 to August 2008 was performed, and studies were classified according to the American Academy of Neurology classification of evidence scheme for a therapeutic article. Recommendations were linked to the strength of the evidence. The results indicate that pregabalin is established as effective and should be offered for relief of PDN (Level A). Venlafaxine, duloxetine, amitriptyline, gabapentin, valproate, opioids (morphine sulfate, tramadol, and oxycodone controlled-release), and capsaicin are probably effective and should be considered for treatment of PDN (Level B). Other treatments have less robust evidence, or the evidence is negative. Effective treatments for PDN are available, but many have side effects that limit their usefulness. Few studies have sufficient information on their effects on function and QOL. [Description provided by NIOSH]
• Subjects:
  Blood Drug Therapy Hematologic Diseases Occupational Health Safety
• Keywords:
  Author Keywords: Efficacy Blood Sugar Disorders Drug Therapy Guidelines Medical Treatment Neuropathic Pain Neuropathy Painful Diabetic Neuropathy Quality Of Life Treatment Options
• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Louisiana ; Maryland ; Michigan ; New Hampshire ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  43
• Issue:
  6
• NIOSHTIC Number:
  nn:20057234
• Citation:
  Muscle Nerve 2011 Jun; 43(6):910-917
• Contact Point Address:
  AANEM, 2621 Superior Drive NW, Rochester, MN 55901
• Email:
  aanem@aanem.org
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Muscle & Nerve
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eda2166e9c0d2790bdf97fa9fbffe143170b0c18e2f746e4fe8960360802444cb95816153eec76931a76d6116b9a088c05a140a05996b26ddd83ffc9d996fe13
• Download URL:
  https://stacks.cdc.gov/view/cdc/214653/cdc_214653_DS1.pdf
• File Type:
  [PDF - 109.23 KB ]