Evidence-Based Guideline: Treatment of Painful Diabetic Neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitatio

Details

• Personal Author:
  Backonja M ; Bril V ; Cohen J ; Del Toro D ; England J ; Feldman E ; Franklin GM ; Iverson DJ ; Perkins B ; Russell JW ; Zochodne D
• Description:
  Objective: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). Methods: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence. The basic question asked was: "What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; and non-pharmacological: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?" Results and Recommendations: Pregabalin is established as effective and should be offered for relief of PDN (Level A). Venlafaxine, duloxetine, amitriptyline, gabapentin, valproate, opioids (morphine sulphate, tramadol, and oxycodone controlled-release), and capsaicin are probably effective and should be considered for treatment of PDN (Level B). Other treatments have less robust evidence or the evidence is negative. Effective treatments for PDN are available, but many have side effects that limit their usefulness, and few studies have sufficient information on treatment effects on function and QOL. [Description provided by NIOSH]
• Subjects:
  Blood Drug Therapy Hematologic Diseases Occupational Health Safety
• Keywords:
  Blood Sugar Disorders Drug Therapy Guidelines Medical Treatment Neuropathy Quality Of Life
• ISSN:
  1934-1482
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Louisiana ; Maryland ; Michigan ; New Hampshire ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  3
• Issue:
  4
• NIOSHTIC Number:
  nn:20057233
• Citation:
  Phys Med Rehabil 2011 Apr; 3(4):345-352.e21
• Contact Point Address:
  American Academy of Neurology, 1080 Montreal Avenue, St. Paul, MN 55116
• Email:
  guidelines@aan.com
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Physical Medicine and Rehabilitation
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9260814af38c9488341ce2f4111a6f86dd08662b2b1f6359f1039909c130957693a2e6760514a4fb64370b7906606db0eb0e9a7fd2a49ed516d87ac79610065c
• Download URL:
  https://stacks.cdc.gov/view/cdc/214652/cdc_214652_DS1.pdf
• File Type:
  [PDF - 163.64 KB ]