Racial/Ethnic Differences in Use and Duration of Adjuvant Hormonal Therapy for Breast Cancer in the Women’s Health Initiative

Details

• Personal Author:
  Chlebowski RT ; Coronado GD ; Erwin DO ; Habel LA ; Hubbell FA ; LaCroix A ; Li CI ; Livaudais JC ; Simon MS ; Thompson B
• Description:
  Background: Five-year breast cancer survival rates are lower among Hispanic and African-American women than among Non-Hispanic White women. Differences in breast cancer treatment likely play a role. Adjuvant hormonal therapies increase overall survival among women with hormone receptor-positive breast cancer. Methods: We examined racial/ethnic differences in use and duration of adjuvant hormonal therapy among 3,588 postmenopausal women enrolled in the Women's Health Initiative (WHI) Extension Study. Women diagnosed with hormone receptor-positive localized or regional stage breast cancer after study enrollment were surveyed between September 2009 and August 2010 and asked to recall prior use and duration of adjuvant hormonal breast cancer therapy. ORs comparing self-reported use and duration with race/ethnicity (Hispanic, African-American, Asian/Pacific Islander vs. Non-Hispanic White) were estimated using multivariable-adjusted logistic regression. Results: Of the 3,588 women diagnosed from 1994 to 2009; 3,039 (85%) reported any use of adjuvant hormonal therapy, and 67% of women reporting ever-use who were diagnosed before 2005 reported using adjuvant hormonal therapy for the optimal duration of 5 years or more. In adjusted analysis, no statistically significant differences in use or duration by race/ethnicity were observed. Conclusions: This study did not find significant differences in use or duration of use of adjuvant hormonal therapy by race/ethnicity. Impact: Findings should be confirmed in other population-based samples, and potential reasons for discontinuation of therapy across all racial/ethnic groups should be explored. [Description provided by NIOSH]
• Subjects:
  Delivery Of Health Care Endocrine System Healthcare Disparities Occupational Health Race Factors Safety Women
• Keywords:
  Breast Cancer Health Disparities Hormones Medical Care Medical Treatment Racial Factors
• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; New York ; Oregon ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  365-373
• Volume:
  22
• Issue:
  3
• NIOSHTIC Number:
  nn:20056905
• Citation:
  Cancer Epidemiol Biomark Prev 2013 Mar; 22(3):365-373
• Contact Point Address:
  Jennifer C. Livaudais, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109
• Email:
  jclivaudais@gmail.com
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:496a16eac4a813918442f3afe06eeb81cdf067d184826e96b5a6b96120420a4bae888f554874f2e01bc55995287a75444c6fdcfc441def8de775e01562559390
• Download URL:
  https://stacks.cdc.gov/view/cdc/214401/cdc_214401_DS1.pdf
• File Type:
  [PDF - 288.42 KB ]