Parkinson’s Disease and History of Outdoor Occupation

Details

• Personal Author:
  Checkoway, Harvey ; Franklin GM ; Gallagher LG ; Kwon E ; Littell CT ; Longstreth WT Jr. ; Searles Nielsen S ; Swanson PD
• Description:
  Background: Human and animal studies, albeit not fully consistent, suggest that vitamin D may reduce risk of Parkinson's disease (PD). Ultraviolet radiation converts vitamin D precursor to the active form. This study examined the hypothesis that working outdoors is associated with a decreased risk of PD. Methods: PD cases were enrolled from Group Health Cooperative, a health maintenance organization in the Puget Sound region in western Washington State, and the University of Washington Neurology Clinic in Seattle. Participants included 447 non-Hispanic Caucasian newly diagnosed PD cases diagnosed between 1992 and 2008 and 578 unrelated neurologically normal controls enrolled in Group Health Cooperative, frequency matched by race/ethnicity, age and gender. Subjects' amount of outdoor work was estimated from self-reported occupational histories. Jobs were categorized by degree of time spent working outdoors. A ten-year lag interval was included to account for disease latency. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression, with adjustment for age, gender, and smoking. Results: Outdoor work was inversely associated with risk of PD (outdoor only compared to indoor only): OR = 0.74, 95% CI 0.44-1.25. However, there was no trend in relation to portion of the workday spent laboring outdoors and PD risk. Conclusion: Occupational sunlight exposure and other correlates of outdoor work is not likely to have a substantial role in the etiology of PD. [Description provided by NIOSH]
• Subjects:
  Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Parkinson's Disease Occupation Occupational Exposure Occupations Outdoor Workers Parkinsons Disease Risk Factors Ultraviolet Radiation Vitamin D Vitamins
• ISSN:
  1353-8020
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  12
• NIOSHTIC Number:
  nn:20056830
• Citation:
  Parkinsonism Relat Disord 2013 Dec; 19(12):1164-1166
• Contact Point Address:
  Harvey Checkoway, University of Washington, Department of Environmental and Occupational Health Sciences, Box 357234, Seattle, WA 98195, United States
• Email:
  checko@u.washington.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Parkinsonism & Related Disorders
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e7b19fc832fb2641aff4633f7f927549cf407ca44fe8025f87dd4da9ff1a0ddafb4aaa27cec7482f7b3d29cd1ebcee5a66786ec79a1a547299d90c82792db76
• Download URL:
  https://stacks.cdc.gov/view/cdc/214336/cdc_214336_DS1.pdf
• File Type:
  [PDF - 78.85 KB ]