Lifetime Occupational and Leisure Time Physical Activity and Risk of Parkinson’s Disease

Details

• Personal Author:
  Krause N ; Liew Z ; Ritz B ; Shih I-F
• Description:
  Introduction: While regular exercise has been shown to alleviate the motor symptoms of Parkinson's disease (PD), it remains unclear whether a physically active lifestyle may prevent PD. Methods: To examine physical activities across the lifespan and risk of PD, we relied on data from a population-based case-control study that enrolled 357 incident PD cases and 341 controls. We assessed physical activity levels via self-report of (1) overall physical activity (PA) over 4 age periods; (2) competitive sports; and (3) occupational histories. Results: PD risks were lower comparing the overall PA highest quartile (moderate to vigorous activities >/=180 metabolic equivalent task-hours/week (MET-h/wk)) with the lowest quartile (<47.8 MET-h/wk) in age-period 18-24 years (adjusted odds ratio (OR) 0.64, 95% confidence interval (CI) 0.40-1.02), and 45-64 years (OR 0.50, 95%CI 0.31-0.83) but not in age-period 25-44. Individuals who consistently engaged in overall PA at high levels (before age 65 years) had a 51% lower PD risk than those with low levels. Also, having participated in competitive sports prior to age 25 was inversely associated with PD (OR 0.53, 95% CI 0.31-0.91 for high level versus never). There was no association for measures of occupational physical activity though. Conclusion: The long prodromal stage of PD makes it difficult to conclude whether insidious disease leads to a reduction of physical activity years before motor symptom onset and PD diagnosis. However, sports activities and high levels of overall PA in youth appear protective unless they are markers for biologic or genetic factors that lower PD risk. [Description provided by NIOSH]
• Subjects:
  Age Factors Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Activity Levels Age Factors Author Keywords: Parkinson's Disease Exercise Occupations Parkinsons Disease Physical Activity Physical Fitness Risk Factors
• ISSN:
  1353-8020
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  112-117
• Volume:
  28
• NIOSHTIC Number:
  nn:20055744
• Citation:
  Parkinsonism Relat Disord 2016 Jul; 28:112-117
• Contact Point Address:
  Beate Ritz, Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA
• Email:
  britz@ucla.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Parkinsonism & Related Disorders
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e9f1428756b83a0c7808d667b37b07e7e57023febb9ad25ecd07d14fd67e3fe8e7edc720930efa494b4d2402a7ebbb6f2563bcd0fb08843d88fff23b5b86f6bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/213525/cdc_213525_DS1.pdf
• File Type:
  [PDF - 229.48 KB ]