Ultrasound Contrast-Enhanced Interrogation of the Median Nerve to Document Peripheral Vascular Flow in an Animal Model

Details

• Personal Author:
  Buford JA ; Evans KD ; Roll SC ; Sommerich CM ; Volz KR
• Description:
  Purpose: To identify dosing and instrumentation while conducting contrast sonography to visualize perineural vascular flow, within the median nerve, in a group of Macaca fascicularis recovering from carpal tunnel syndrome (CTS). Material & Methods: A pilot dosing study was conducted with Macaca fascicularis, which were trained to complete a repetitive task. Nerve conduction and gray-scale sonography data were collected on 8 subjects with documented CTS. The dosing study facilitated the capture of vascular fill time within both large and small vessels. Dosing and instrumentation were set using the subclavian and radial artery, to determine a mean vascular fill time. The Doppler studies were conducted with a GE Logiq 9 and a 9 MHz linear array transducer. Definity(R) was mixed with saline to provide an infusion contrast injection. Four injections and booster shots were administered while the subject was closely monitored. Results: A transmit frequency of 6.0 MHz, MI of 0.13, and 7% output power was coupled with an infusion of 0.04 ml of Definity(R) and 0.8 ml saline. Booster infusions of 0.05 facilitated the capture of a vascular fill time of 1:30 mins in the subclavian and radial artery. The perineural vascular fill time was similar with these same infusion and equipment settings. Conclusion: Although data was collected on 8 subjects, more subject results would provide convincing results on the vascular fill time associated with perineural vascular flow, post CTS diagnosis. [Description provided by NIOSH]
• Subjects:
  Animals Musculoskeletal System Nervous System Occupational Health Safety
• Keywords:
  Animal Studies Imaging Techniques Nerves Nerve Tissue Ultrasound Upper Extremities
• ISSN:
  0301-5629
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  37
• Issue:
  8
• NIOSHTIC Number:
  nn:20056568
• Citation:
  Ultrasound Med Biol 2011 Aug; 37(8)(Suppl):S6
• Federal Fiscal Year:
  2011
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  False
• Start Date:
  20100901
• Source Full Name:
  Ultrasound in Medicine & Biology
• Supplement:
  Supplement
• End Date:
  20130430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5fad18a75816e5cbecd30c217b63ae37c8211711c6df9807784399d8206bd2949be9f050a2b8ae11f41a5eb5f1342743f9b41d05311f7bbac52865216e8245d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/214151/cdc_214151_DS1.pdf
• File Type:
  [PDF - 32.97 KB ]