Translating Contrast-Enhanced Ultrasound Intraneural Vascularity from Bench to Bedside

Details

• Personal Author:
  Evans K ; Volz K
• Description:
  Objectives-To describe contrast-enhanced ultrasound (CEUS) imaging of the human median nerve's intraneural vascularity, with equipment settings and optimizations derived from experiments with a cohort of Macaca fascicularis. Methods-The equipment used was a GE LOGIQ 9, complete with contrast settings, and a GE LOGIQ i, which is considered a handcarried unit. A 9.0-MHz linear broadband transducer was used with the GE LOGIQ 9, and a 12.0-MHz linear broadband transducer was used with the GE LOGIQ i hand-carried unit. Definity was used for this study because it possesses the smallest microspheres, 1.1 to 1.3 um, has stability of <10 minutes, and resonates at 4 MHz. Equipment settings that had been used with experiments conducted with 11 M fascicularis were repeated with 11 patients during a CEUS echocardiogram. PixelFlux Scientific soft- ware allowed for semiautomatic assessment of the intensity of the contrast pixels. Descriptive statistics are compared to pixel counts and intensities between humans and the monkeys, although contrast dosing amounts varied. The goal was to capture multi-incremental sampling of the images during CEUS, focused on the median nerve. Results-The GE LOGIQ equipment settings were applied to the human study based on previous experiments. A better visual yield was found with 4% output power and a mechanical index of 0.13; these translated settings provided optimum imaging of the median nerve. The 9.0- MHz linear transducer was also downshifted to a transmit frequency of 6.0 MHz for the human studies. Trend graphs are provided for comparison purposes. Conclusions-It will be vital to replicate this pilot study to validate these results with a larger set of subjects and correlate the findings with nerve conduction studies. Higher levels of evidence will promote the use of CEUS to investigate intraneural vessels and allow for angle correction, thereby yielding increased accuracy. [Description provided by NIOSH]
• Subjects:
  Animals Musculoskeletal Diseases Musculoskeletal System Nervous System Occupational Health Safety
• Keywords:
  Animal Studies Carpal Tunnel Syndrome CTS Nerves Nerve Tissue Ultrasound Upper Extremities
• ISSN:
  0278-4297
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• NIOSHTIC Number:
  nn:20057684
• Citation:
  J Ultrasound Med 2013 Apr; 32(Suppl):S24
• Federal Fiscal Year:
  2013
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Journal of Ultrasound in Medicine. American Institute of Ultrasound in Medicine 2013 Annual Convention, April 6-10, 2013, New York
• Supplement:
  Supplement
• End Date:
  20130430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1206db2c7b010f2925a708a97c07394b8ca6a943ff847f199a45d7063834541565a484753332b5af0e90fea8ca6a6b131ea166c1cf9b03fc6ad87225a4453433
• Download URL:
  https://stacks.cdc.gov/view/cdc/214945/cdc_214945_DS1.pdf
• File Type:
  [PDF - 49.43 KB ]