Associations Between Mixtures of Urinary Phthalate Metabolites with Gestational Age at Delivery: A Time to Event Analysis Using Summative Phthalate Risk Scores

Details

• Personal Author:
  Aung MT ; Boss J ; Ferguson KK ; Johns LE ; McElrath TF ; Meeker JD ; Mukherjee B ; Zhai J
• Description:
  Background: Preterm birth is a significant public health concern and exposure to phthalates has been shown to be associated with an increased odds of preterm birth. Even modest reductions in gestational age at delivery could entail morbid consequences for the neonate and analyzing data with this additional information may be useful. In the present analysis, we consider gestational age at delivery as our outcome of interest and examine associations with multiple phthalates. Methods: Women were recruited early in pregnancy as part of a prospective, longitudinal birth cohort at the Brigham and Women's Hospital in Boston, Massachusetts. Urine samples were collected at up to four time points during gestation for urinary phthalate metabolite measurement, and birth outcomes were recorded at delivery. From this population, we selected all 130 cases of preterm birth (
• Subjects:
  Biomarkers Environmental Exposure Occupational Health Phthalic Acids Pregnancy Safety Women
• Keywords:
  Author Keywords: Hazard Ratio Environmental Exposure Environmental Risk Score Mixtures Phthalate Phthalates Prenatal Exposure Time To Delivery
• ISSN:
  1476-069X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  56
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:20056535
• Citation:
  Environ Health 2018 Jun; 17(1):56
• Contact Point Address:
  Bhramar Mukherjee, Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA
• Email:
  bhramar@umich.edu
• CAS Registry Number:
  Monoethyl phthalate (CAS RN 2306-33-4)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health: A Global Access Science Source
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2683f6d1cd3b802cecb0bdf81b5a93bb12192113acaac1c715ece9ec6c1351fd579c9f4956f88ef9a89a9af64f2ac039933a0a163de944f2455f9b13404f490
• Download URL:
  https://stacks.cdc.gov/view/cdc/214126/cdc_214126_DS1.pdf
• File Type:
  [PDF - 786.79 KB ]