Urinary Phthalate Metabolite Concentrations in Relation to Levels of Circulating Matrix Metalloproteinases in Pregnant Women

Details

• Personal Author:
  Bedrosian LD ; Cantonwine DE ; Ferguson KK ; McElrath TF ; Meeker JD
• Description:
  Phthalate exposure has been shown to be associated with adverse pregnancy outcomes. However, human studies informing relevant mechanistic pathways are lacking. Experimental studies have reported that matrix metalloproteinases (MMPs), which are responsible for extracellular protein degradation, may be upregulated in response to phthalate exposure. In this exploratory study we measured urinary phthalate metabolite concentrations, plasma MMP levels, and relevant covariates among 134 pregnant women. There were statistically significant or suggestive positive relationships between several phthalates, particularly between metabolites of di-(2-ethylhexyl) phthalate, with MMP-1 and MMP-9 levels. Further research is needed to confirm these results and how they may inform the mechanisms involved between phthalate exposure and adverse pregnancy outcomes. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environment Epidemiology Occupational Health Phthalic Acids Pregnancy Safety Women
• Keywords:
  Author Keywords: Biomarker Enzyme Exposure Exposure Assessment Phthalates Prenatal Exposure Proteins
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  613
• NIOSHTIC Number:
  nn:20056680
• Citation:
  Sci Total Environ 2018 Feb; 613-614:1349-1352
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan School of Public Health, 1835 SPH I, 1415 Washington Heights, Ann Arbor, MI 48109, United States
• Email:
  meekerj@umich.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Science of the Total Environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab18420ae0e3c4dae689cd6b4f80fe3887cbd99bc6d92110fce502ef09f8850030969c7bf12f833e9045f93066673fa073097b501fc47f9f478d6e12189d4763
• Download URL:
  https://stacks.cdc.gov/view/cdc/214235/cdc_214235_DS1.pdf
• File Type:
  [PDF - 252.79 KB ]