Urinary Metal Concentrations Among Mothers and Children in a Mexico City Birth Cohort Study

Details

• Personal Author:
  Basu N ; Cantoral A ; Gauthier AM ; Lewis RC ; Meeker JD ; Mercado-García A ; Peterson KE ; Téllez-Rojo MM ; Watkins DJ
• Description:
  Personal care product use is a potential source of metals exposure among children, but studies have been limited. We measured urinary concentrations of 10 metals (aluminum, arsenic [As], barium [Ba], cadmium, cobalt [Co], lead [Pb], manganese [Mn], molybdenum [Mo], nickel, and zinc [Zn]) in third trimester pregnant women (n = 212) and their children at 8-14 years of age (n = 250). Demographic factors (child sex, age, socioeconomic status, and maternal education), body mass index (BMI) z-score, and child personal care product use in the 24 h prior to urine collection were examined as predictors of urinary metal concentrations. Metals were detected in 80-100% of urine samples, with significant differences in maternal versus childhood levels. However, metal concentrations were not strongly correlated within or between time points. In linear regression models including all demographic characteristics, BMI z-score, and specific gravity, age was associated with higher Co (6% [95% CI: 2, 10]), while BMI z-score was associated with lower Mo (-6% [95% CI: -11, -1). In addition, significantly higher metal concentrations were observed among users of colored cosmetics (Mo: 42% [95% CI: 1, 99]), deodorant (Ba: 28% [3, 58]), hair spray/hair gel (Mn: 22% [3, 45]), and other toiletries (As: 50% [9, 108]), as well as with an increasing number of personal care products used (As: 7% [3, 11]) after adjustment for child sex, age, total number of products used, and specific gravity. However, significantly lower metal concentrations were noted for users of hair cream (As and Zn: -20% [-36, -2] and -21% [-35, -2], respectively), shampoo (Pb: -40% [-62, -7]), and other hair products (Pb: -44% [-65, -9]). We found that personal care product use may be a predictor of exposure to multiple metals among children. Further research is recommended to inform product-specific exposure source identification and related child health risk assessment efforts. [Description provided by NIOSH]
• Subjects:
  Cosmetics Metals Occupational Health Pregnancy Safety
• Keywords:
  Author Keywords: Biomarkers Children Exposure Hair Care Products Personal Care Products Prenatal Exposure
• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  221
• Issue:
  4
• NIOSHTIC Number:
  nn:20056494
• Citation:
  Int J Hyg Environ Health 2018 May; 221(4):609-615
• Contact Point Address:
  Deborah J. Watkins, University of Michigan School of Public Health, Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI, 48109, USA
• Email:
  debjwat@umich.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:35f96d9b2134869a7df994b41fb5982c0b3649cb4cb874aeefd5cd0c3e2bc72bfbec07ecdca716dcd32a4feeee78c2327e32977ba3a917e1f9b29d9bca5c8732
• Download URL:
  https://stacks.cdc.gov/view/cdc/214093/cdc_214093_DS1.pdf
• File Type:
  [PDF - 274.26 KB ]