Urinary metal concentrations among mothers and children in a Mexico City birth cohort study

Details

• Alternative Title:
  Int J Hyg Environ Health
• Personal Author:
  Lewis, Ryan C. ; Meeker, John D. ; Basu, Niladri ; Gauthier, Alison M. ; Cantoral, Alejandra ; Mercado-García, Adriana ; Peterson, Karen E. ; Téllez-Rojo, Martha Maria ; Watkins, Deborah J.
• Description:
  Personal care product use is a potential source of metals exposure among children, but studies have been limited. We measured urinary concentrations of 10 metals (aluminum, arsenic [As], barium [Ba], cadmium, cobalt [Co], lead [Pb], manganese [Mn], molybdenum [Mo], nickel, and zinc [Zn]) in third trimester pregnant women (n = 212) and their children at 8-14 years of age (n = 250). Demographic factors (child sex, age, socioeconomic status, and maternal education), body mass index (BMI) z-score, and child personal care product use in the 24 h prior to urine collection were examined as predictors of urinary metal concentrations. Metals were detected in 80-100% of urine samples, with significant differences in maternal versus childhood levels. However, metal concentrations were not strongly correlated within or between time points. In linear regression models including all demographic characteristics, BMI z-score, and specific gravity, age was associated with higher Co (6% [95% CI: 2, 10]), while BMI z-score was associated with lower Mo (-6% [95% CI: -11, -1). In addition, significantly higher metal concentrations were observed among users of colored cosmetics (Mo: 42% [95% CI: 1, 99]), deodorant (Ba: 28% [3, 58]), hair spray/hair gel (Mn: 22% [3, 45]), and other toiletries (As: 50% [9, 108]), as well as with an increasing number of personal care products used (As: 7% [3, 11]) after adjustment for child sex, age, total number of products used, and specific gravity. However, significantly lower metal concentrations were noted for users of hair cream (As and Zn: -20% [-36, -2] and -21% [-35, -2], respectively), shampoo (Pb: -40% [-62, -7]), and other hair products (Pb: -44% [-65, -9]). We found that personal care product use may be a predictor of exposure to multiple metals among children. Further research is recommended to inform product-specific exposure source identification and related child health risk assessment efforts.
• Subjects:
  Adolescent Arsenic Child Cities Cohort Studies Cosmetics Environmental Monitoring Environmental Pollutants Female Humans Male Metals Mexico Mothers Pregnancy Pregnancy Trimester, Third

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• Keywords:
  Biomarkers Children Exposure Metals Personal Care Products Pregnancy
• Source:
  Int J Hyg Environ Health. 221(4):609-615
• Pubmed ID:
  29703512
• Pubmed Central ID:
  PMC6197859
• Document Type:
  Journal Article
• Funding:
  P01 ES022844/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; R01 ES021446/ES/NIEHS NIH HHSUnited States/ ; T42 OH008455/OH/NIOSH CDC HHSUnited States/
• Volume:
  221
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:66025224da12f61093aecb49b32f8ab27dda8f853b4f8dc4b0f867f568a8f913
• Download URL:
  https://stacks.cdc.gov/view/cdc/76896/cdc_76896_DS1.pdf
• File Type:
  [PDF - 112.10 KB ]