Air Pollution and Inflammation: Findings from Concurrent Repeated Measures of Systemic and Reproductive Tract Cytokines During Term Pregnancy in Mexico City

Details

• Personal Author:
  Buxton MA ; Foxman B ; Gronlund CJ ; Meraz-Cruz N ; O'Neill MS ; Sanchez BN ; Vadillo-Ortega F
• Description:
  Background: Environmental exposures are associated with a number of outcomes including adverse pregnancy outcomes. Although inflammation is hypothesized to play a role, the mechanistic pathways between environmental exposures and adverse health outcomes, including associations between exposures and longitudinal measures of systemic and reproductive tract inflammation, need elucidation. Objectives: This study was conducted to evaluate whether exposure to air pollution is associated with immunologic responses in the systemic circulation and lower reproductive tract, and to evaluate whether systemic and reproductive tract immunologic responses are similar. Methods We quantified repeated measures of cytokines from cervico-vaginal exudates and serum obtained concurrently among 104 women with term pregnancies and estimated PM10 and CO exposure using the monitor nearest each participant's residence. Serum and cervico-vaginal cytokines were compared using Wilcoxon signed-ranks test and Spearman rank correlations for select gestational months. We used intraclass correlation coefficients (ICCs) to quantify reproducibility of cytokine measurements, and Tobit regression to estimate associations between air pollution and cytokines. Results: Median cervico-vaginal levels of IL-6, Eotaxin, IP-10, MCP-1, MIP-1a, MIP-1B, and TNFa were higher than corresponding serum cytokines, significantly so for IL-6 and IP-10. Cervico-vaginal and serum cytokines were not correlated, but cytokines from the same fluid were correlated. ICCs for most serum cytokines were =0.40, while ICCs were higher in cervico-vaginal cytokines (range 0.52-0.83). IP-10 and Eotaxin had the highest ICCs for both cytokine sources. In adjusted models, PM10 was positively associated with serum cytokines IL-6, IP-10, MIP-1B and Eotaxin but inversely associated with cervico-vaginal cytokine TNFa, IP-10, MIP-1B, MCP-1 and Eotaxin, controlling for false discovery rate. CO was inversely associated with cervico-vaginal TNFa, IL-6, MIP-1B, MCP-1 and Eotaxin. Conclusions: Inflammatory processes are compartment-specific. Systemic inflammatory markers may provide information on immunologic processes and response to environmental exposures, but are not proxies for lower reproductive tract inflammation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Environmental Pollution Occupational Health Pregnancy Safety Urogenital System Women
• Keywords:
  Author Keywords: Environmental Pollution Cervico-vaginal Cytokines Environmental Contamination Environmental Exposure Longitudinal Data Maternal Inflammation PRINCESA Cohort Reproductive Hazards Serum Cytokines
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  235-241
• Volume:
  681
• NIOSHTIC Number:
  nn:20056443
• Citation:
  Sci Total Environ 2019 Sep; 681:235-241
• Contact Point Address:
  Miatta A. Buxton, University of Michigan School of Public Health, 1415 Washington Heights, Rm 6665, Ann Arbor, MI 48109-2029, United States of America
• Email:
  mabuxton@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Science of the Total Environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dea2608efc82f498a979c37b6653b193fa98b201fb5000aa349632f875bc6a2c6d14e2ad8588e581919f2a5644ebb36cd90d0243f939c432fefede0b114b2345
• Download URL:
  https://stacks.cdc.gov/view/cdc/214049/cdc_214049_DS1.pdf
• File Type:
  [PDF - 627.58 KB ]