Reliability of Serial Urine HCG as a Biomarker to Detect Early Pregnancy Loss

Details

• Personal Author:
  Chen C ; Cho SI ; Christiani, David C. ; Damokosh AI ; Goldman MB ; Lasley BL ; O'Connor JF ; Ryan LM ; Wilcox AJ ; Xu X
• Description:
  BACKGROUND: To examine the reliability of HCG as a biomarker for early pregnancy loss, five experienced researchers independently assessed data from 153 menstrual cycles, determining whether each cycle represented 'no conception,' a 'continuing conception' or a 'conception lost.' METHODS: Urine samples were analysed by immunoradiometric assay using a combination of capture antibodies for the intact heterodimer (B109) and for an epitope common to the beta subunit and the beta core fragment (B204). For each cycle, HCG data were presented as graphs of daily assay results. Summary statistics for HCG assays from 46 women who had undergone bilateral tubal ligation represented baseline values. RESULTS: Pairwise agreement among the assessors for any of the three options ranged from 78-89%. At least three experts agreed for 147 cycles (96%), accounting for 28 conception losses and 19 continuing conceptions. The multi-rater kappa was 0.62 for the conception lost category and 0.68 for continuing conceptions, indicating substantial agreement. CONCLUSION: The main sources of disagreement involved deciding whether there was sufficient information for assessment, interpreting cycle parameters such as cycle length or bleeding event, and interpreting a distinct HCG rise pattern that does not exceed the baseline value obtained from the sterilized women. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Pregnancy Safety Urogenital Diseases Urogenital System Women
• Keywords:
  Reproductive Hazards Reproductive System Disorders
• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  4
• NIOSHTIC Number:
  nn:20029483
• Citation:
  Hum Reprod 2002 Apr; 17(4):1060-1066
• Contact Point Address:
  Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC and 8 Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
• CAS Registry Number:
  Ammonia (CAS RN 7664-41-7) ; Benzene (CAS RN 71-43-2) ; Hydrogen sulfide (CAS RN 7783-06-4) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Disease and Injury: Fertility and Pregnancy Abnormalities
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19921201
• Source Full Name:
  Human Reproduction
• End Date:
  19990131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:327540eb0d6f8bdfd7c5b2142253978722e003024364d1514e03eba7afc223e127c123c098451110665a17216a4e54c07c224cd4a306c0e30f63686c56ca6869
• Download URL:
  https://stacks.cdc.gov/view/cdc/190449/cdc_190449_DS1.pdf
• File Type:
  [PDF - 85.30 KB ]