Insufficient Zinc Intake Enhances Lung Inflammation in Response to Agricultural Organic Dust Exposure

Details

• Personal Author:
  Hanson CK ; Heires AJ ; Knoell DL ; Poole JA ; Romberger DJ ; Sapkota M ; Smith DA ; Smith LM ; Wyatt TA
• Description:
  Organic dust exposure particularly within hog confinement facilities is a significant cause of airway inflammation and lung disease. In a cohort of Midwestern veterans with COPD and agricultural work exposure we observed reduced zinc intakes which were associated with decreased lung function. Because insufficient zinc intake is common within the U.S. and a potent modulator of innate immune function, we sought to determine whether deficits in zinc intake would impact the airway inflammatory response to hog confinement facility dust extract (HDE). Adult male C57BL/6 mice were randomized to zinc deficient or matched zinc sufficient diets for 3 weeks and subsequently treated with intranasal HDE inhalation or saline once or daily for 3 weeks while maintained on specific diets. Lavage fluid and lung tissue was collected. Conditions of zinc deficiency were also studied in macrophages exposed to HDE. Single and repetitive HDE inhalation exposure resulted in increased influx of total cells and neutrophils, increased mediator hyper-responsiveness (TNFa, IL-6, CXCL1, and amphiregulin), and enhanced tissue pathology that was more pronounced in zinc deficient mice compared to normal dietary counterparts. Airway inflammation was most pronounced in zinc deficient mice treated with repetitive HDE for 3 weeks. Similarly, macrophages maintained in a zinc deficient environment exhibited increased CXCL1 and IL-23 production as a result of increased NF-kB activation. Conclusion: Given the relatively high incidence of dietary deficiencies in agriculture workers, we anticipate that zinc intake, or a lack thereof, may play an important role in modulating the host response to organic dust exposure. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Confined Spaces Dust Laboratories Lung Lung Diseases Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Agricultural Workers Author Keywords: Inflammation Confined Spaces Innate Immunity Laboratory Animals Lung Disease Lung Irritants Organic Dust Organic Dusts Zinc
• ISSN:
  0955-2863
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  56-64
• Volume:
  70
• NIOSHTIC Number:
  nn:20056370
• Citation:
  J Nutr Biochem 2019 Aug; 70:56-64
• Contact Point Address:
  Daren L. Knoell, College of Pharmacy, Room 2039 The University of Nebraska Medical Center 986120 Nebraska Medical Center, Omaha, NE 68198-6120
• Email:
  daren.knoell@unmc.edu
• CAS Registry Number:
  Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  The Journal of Nutritional Biochemistry
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb024708de800b1a683c54874d8820c86664e318f1e95c076d8e9b147888bd9af3488b0631c6a108fa74d6d86358b32088338ed63f5b32c4ea83b206dc15f132
• Download URL:
  https://stacks.cdc.gov/view/cdc/213992/cdc_213992_DS1.pdf
• File Type:
  [PDF - 457.57 KB ]