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Dermal Penetration Modeling: What’s New? How Do You Use It?



Details

  • Personal Author:
    Kasting GB
  • Description:
    A new method for calculating transient transport of low to moderate quantities of volatile organic compounds contacting the skin will be described. The method applies to non corrosive organic chemicals contacting the skin either as neat liquids or as simple solutions. It is specifically designed for use with pesticides and non-corrosive solvents and is undergoing ongoing testing with these materials in our laboratory. Input parameters to the calculation include the specific dose in micrograms/cm2, physical properties of the compound (molecular weight, partition coefficient, ionization constant(s), density, water solubility and vapor pressure), temperature, wind velocity and skin hydration state. Outputs include amounts absorbed and evaporated as a function of time, as well as the transient concentration profile of the permeant in the various skin layers. The calculation is implemented in an Excel(R) spreadsheet with an add-in for solving the transient diffusion problem. The transient skin transport model, an ongoing development, provides a new tool for estimating systemic absorption of organic chemicals following limited dermal exposures. It may also be used to some advantage for steady-state absorption problems including maximum flux calculations. A recent application involves estimation of the epidermal concentrations of contact allergens following small topical exposures. In this context, the method is under consideration as a component of an animal-free risk assessment package for quantifying the risk of contact allergy associated with cosmetic and personal care products. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISBN:
    9780918062187
  • Publisher:
    Colorado School of Mines
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Abstract or Summary
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    24
  • NIOSHTIC Number:
    nn:20056132
  • Citation:
    OEESC 2007: 3rd International Conference on Occupational and Environmental Exposure of Skin to Chemicals, June 17-20, 2007, Golden, Colorado. Golden, CO: Colorado School of Mines, June 2007; :24
  • Federal Fiscal Year:
    2007
  • Performing Organization:
    University of Cincinnati
  • Peer Reviewed:
    False
  • Start Date:
    20020901
  • Source Full Name:
    OEESC 2007: 3rd International Conference on Occupational and Environmental Exposure of Skin to Chemicals, June 17-20, 2007, Golden, Colorado
  • End Date:
    20130731
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:2f3de7f20fe014199c34b3e95b3586fe89335febf2147ab584eda10cecf3807724cb3e2015ecdf686a4f4d7252b2c1917e02a7336ce84effc2625909609fe9ff
  • Download URL:
  • File Type:
    Filetype[PDF - 162.85 KB ]
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