Assessment of Indoor Dermal Exposure to SVOCs

Details

• Personal Author:
  Cousins AC ; Kissel JC ; Shirai JH
• Description:
  Background and Purpose/Objectives: Increasingly available biomonitoring data provide evidence of widespread human exposure to large numbers of chemicals. In some cases, dominant exposure pathways are evident. However, in the case of non-occupational exposures to chemicals found in consumer products, multiple exposure pathways may be relatively important contributors. Although attempts to parse aggregate exposures are becoming common, data sets that actually permit use of a mass balance approach remain relatively rare. Even where mass balance is possible, use of uncertain or conservative estimates may conceal a gap between the sum of predicted inputs and observed outputs. Aggregate assessments often contain component estimates that vary dramatically in quality. Dermal exposures in particular are often dismissed on the basis of calculations that are not well considered. Methodology: Potential exposures are evaluated using a fugacity-based indoor fate and transport model linked to a multi-component human PBPK model with a credible (i.e., membrane) skin barrier. Results/Impact/Outcomes: Dermal exposures appear to contribute non-negligibly to expression of biomarkers for multiple indoor contaminants including pesticides, flame retardants, plasticizers and nicotine. Cross chemical comparisons can provide insight into exposure factor estimates that provide consistent explanations. Conclusions and Discussion: In the case of SVOCs that persist in indoor environments, chronic dermal exposures are inevitable. Credible estimates of the magnitude of those exposures are needed to inform future consumer product regulations. [Description provided by NIOSH]
• Subjects:
  Occupational Health Risk Assessment Risk Factors Safety Skin Skin Absorption
• Keywords:
  Biomonitoring Chemicals Dermal Absorption Indoor Environments Risk Factors Skin Absorption
• Publisher:
  University of Toronto
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  41
• NIOSHTIC Number:
  nn:20056100
• Citation:
  OEESC 2011: 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals, June 5-8, 2011, Toronto, Canada. Toronto, Canada: University of Toronto, June 2011; :41
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20020901
• Source Full Name:
  OEESC 2011: 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals, June 5-8, 2011, Toronto, Canada
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a2b816c626c3c1769ac5aa806df0e7edbb79072c57a8f29d080a52e394cc8cb66d228f96f709aa3d5f69055f4074153c09e81bb0407d3741cfbec921972ce71
• Download URL:
  https://stacks.cdc.gov/view/cdc/213778/cdc_213778_DS1.pdf
• File Type:
  [PDF - 183.38 KB ]