Redox (Phospho)lipidomics of Signaling in Inflammation and Programmed Cell Death

Details

• Personal Author:
  Amoscato AA ; Anthonymuthu TS ; Bayir H ; Bolevich SB ; Dar HH ; Epperly MW ; Greenberger JS ; Kagan VE ; Kapralov AA ; Kellum JA ; Kisin ER ; Krysko DV ; Krysko O ; Mallampalli RK ; Popova EN ; Shvedova AA ; St. Croix CM ; Timashev PS ; Tyurin VA ; Tyurina YY ; Vlasova II ; Watkins SC ; Watson AM ; Wenzel SE
• Description:
  In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall overwhelmingly complex network of interactions triggered by inflammation, will lead to the discovery of new small molecule regulators and therapeutic modalities. For example, suppression of the production of AA-derived pro-inflammatory mediators, HXA(3) and LTB(4), by an iPLA(2)gamma inhibitor, R-BEL, mitigated injury associated with the activation of pro-inflammatory processes in animals exposed to whole-body irradiation. Further, technological developments promise to make redox lipidomics a powerful approach in the arsenal of diagnostic and therapeutic instruments for personalized medicine of inflammatory diseases and conditions. [Description provided by NIOSH]
• Subjects:
  Immune System Lipids Occupational Health Pathology Radiation Safety
• Keywords:
  Author Keywords: Eicosanoids Biosynthesis Cell Biology Cell Death Cell Signaling Cellular Function Chronic Inflammation Enzymatic Effects Enzyme Inhibitors Gene Expression Gene Regulation Hydrolysis Immune Reaction Immune System Irradiation Lipases Lipid Mediators Lipid Peroxidation Lipoxygenase Molecular Signaling Molecular Structure Oxidation Reduction Reactions Oxidative Phosphorylation Oxidized Phospholipids Oxidizers Peroxidation Phospholipase A2 Phospholipid Hydrolysis Phospholipids Physiological Effects Signaling Pathways Unsaturated Compounds

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• ISSN:
  0741-5400
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  57-81
• Volume:
  106
• Issue:
  1
• NIOSHTIC Number:
  nn:20055977
• Citation:
  J Leukoc Biol 2019 Jul; 106(1):57-81
• Contact Point Address:
  Valerian E. Kagan, Department of Environmental and Occupational Health, University of Pittsburgh, Room 4120, 130 De Soto Street, Pittsburgh, PA 15219, USA
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Mining
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Leukocyte Biology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e800229ab41c430d36bab4afedd106e018fe1903ee509e7001ac29642d9583d2d3e8b1a10aea1379f41a0e8569bd7417084b36d9d232d6d0e31a0d7ea710897
• Download URL:
  https://stacks.cdc.gov/view/cdc/213713/cdc_213713_DS1.pdf
• File Type:
  [PDF - 1.53 MB ]