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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study Between Los Angeles and Beijing



Details

  • Personal Author:
  • Description:
    Air pollution is among the top threats to human health in China. As air toxicants, polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to population; however, the exposure to PAHs in China and its health impact are not fully understood. In 2012, a summer exchange program allowed 10 students to travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the program, this study investigated the difference in urinary concentration of 12 hydroxylated-PAHs (S12OH-PAHs) and malondialdehyde (MDA) between the two cities. The median concentration of S12OH-PAHs in Beijing (14.1 ug g-1 creatinine) was significantly higher than that in Los Angeles (5.78 ug g-1 creatinine), indicating a higher exposure in Beijing. The ratios of homogeneous OH-PAHs (e.g., 1-/2-OH-NAP) changed significantly between the two cities (p < 0.01), which might suggest a potential alteration in metabolism subsequent to exposure. A significant association between S12OH-PAHs and MDA (p < 0.01) was observed, with the association varying between the two cities. This study suggests that exposure to PAHs might be linked to metabolism alteration and calls for future studies to investigate the role this possible alteration played in the health effects of PAHs exposure. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0013-936X
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    50
  • Issue:
    7
  • NIOSHTIC Number:
    nn:20055749
  • Citation:
    Environ Sci Technol 2016 Apr; 50(7):3738-3745
  • Contact Point Address:
    Yifang Zhu, Department of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California 90095, United States
  • Email:
    yifang@ucla.edu
  • CAS Registry Number:
    Creatinine (CAS RN 60-27-5)
  • Federal Fiscal Year:
    2016
  • Performing Organization:
    University of California Los Angeles
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Environmental Science and Technology
  • End Date:
    20270630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:21d1e37340e99c411383cb1b3ea491dedf3a55734e96a4025b1e4e183779ed6e73b5fbccb60e3f2bcfe12dcf24404b1fff5aecb9d93764389928afe10fa87558
  • Download URL:
  • File Type:
    Filetype[PDF - 745.26 KB ]
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