Distribution and Predictors of Urinary Polycyclic Aromatic Hydrocarbon Metabolites in Two Pregnancy Cohort Studies

Details

• Personal Author:
  Alshawabkeh A ; Cantonwine DE ; Cathey A ; Cordero JF ; Ferguson KK ; McElrath TF ; Meeker JD ; Pace G
• Description:
  Pregnant women and their fetuses represent susceptible populations to environmental contaminants. Exposure to polycyclic aromatic hydrocarbons (PAHs) among pregnant women may contribute to adverse birth outcomes such as preterm birth. Multiple previous studies have assessed airborne sources of PAHs among pregnant women but few have measured urinary PAH metabolites which can capture total exposure through multiple routes. The aim of this study was to bridge this knowledge gap by assessing longitudinal urinary PAH metabolite concentrations over two time points in pregnancy cohorts in Boston (N = 200) and Puerto Rico (N = 50) to better understand exposure distributions throughout pregnancy and how they relate to demographic factors. Urine samples were analyzed for 1-NAP, 2-NAP, 2-FLU, 1-PHE, 2,3-PHE, 4-PHE, 9-PHE, and 1-PYR. Concentrations of 2-NAP, 1-PYR, and 4-PHE were higher in Puerto Rico, while all other metabolites were present in higher concentrations in Boston. In Puerto Rico, intraclass correlation coefficients (ICC) were weak to moderate, ranging from 0.06 to 0.42. PAH metabolite concentrations were significantly higher among younger, heavier (except 1-NAP and 9-PHE), and less educated individuals in Boston only. Consistent significant associations between PAH concentrations and measured covariates were not found in Puerto Rico. Our results suggest that potentially important differences in PAH exposure exist between these two populations. Additionally, our results indicate that multiple urinary measurements are required to accurately assess PAH exposure throughout pregnancy. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Environmental Exposure Hydrocarbons Occupational Health Polycyclic Aromatic Hydrocarbons Pregnancy Safety
• Keywords:
  Author Keywords: Pregnancy Cohort Studies Environmental Exposure Exposure Assessment Polycyclic Aromatic Hydrocarbons Prenatal Exposure
• ISSN:
  0269-7491
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; Michigan ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; Puerto Rico
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  232
• NIOSHTIC Number:
  nn:20056679
• Citation:
  Environ Pollut 2018 Jan; 232:556-562
• Contact Point Address:
  John D. Meeker, Room 1835 SPH I, 1415 Washington Hts, Ann Arbor, MI 48109, USA
• Email:
  meekerj@umich.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Pollution
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48c84d0ec9efcaaac31876cc74360d7a8e3409d4dbde3b0e3cedf6f54acc3683d86c9d93d42804aa9d48c59e9e6b5ac5116cb3d4162d173f566fda5bbb9a3cbc
• Download URL:
  https://stacks.cdc.gov/view/cdc/214234/cdc_214234_DS1.pdf
• File Type:
  [PDF - 691.11 KB ]