A Brief Overview of HPLC-MS Analysis of Alkyl Methylphosphonic Acid Degradation Products of Nerve Agents

Details

• Personal Author:
  B'Hymer CB
• Description:
  The analysis of degradation products from the classic chemical warfare nerve agents by high-performance liquid chromatography-mass spectrometry has been of much interest in recent years owing to the possible use as a terrorist weapon, and the incidents of chemical weapon usage in recent years in war torn countries. The alkyl methylphosphonic acid degradation products are of a particular interest, and they represent a specific chromatographic technical challenge for use in typical separation systems. Various published methods are summarized in this review and some of the problems associated with the analysis of these compounds are discussed. Future trends of the analysis in this area of research are also considered. [Description provided by NIOSH]
• Subjects:
  Chemistry Chromatography Nervous System Occupational Health Safety
• Keywords:
  Analytical Instruments Analytical Methods Analytical Processes Chemical Agents Chemical Analysis Chemical Indicators Chemical Warfare Agents Chromatographic Analysis Liquid Chromatography Mass Spectrometry Neurotoxic Agents

  More +
• ISSN:
  0021-9665
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  7
• NIOSHTIC Number:
  nn:20055687
• Citation:
  J Chromatogr Sci 2019 Aug; 57(7):606-617
• Contact Point Address:
  Clayton B'Hymer, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 1090 Tusculum Avenue, Cincinnati, OH 45226, USA
• Email:
  cbhymer@cdc.gov
• CAS Registry Number:
  Methylphosphonic acid (CAS RN 993-13-5)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Chromatographic Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:278f14fcdff2e74318c336bacac55b76992b78ab13c171037cae37b75b2845531042b08dd198af6644535a42efa449b9cdfe481cf6b479a2f85e801a736b92b0
• Download URL:
  https://stacks.cdc.gov/view/cdc/213477/cdc_213477_DS1.pdf
• File Type:
  [PDF - 598.52 KB ]