Chemical warfare agent degradation products: HPLC-MS analysis.

Details

• Personal Author:
  B'Hymer, Clayton
• Description:
  High-performance liquid chromatography-mass spectrometry (HPLC-MS) has become a commonly used analytical technique for the analysis of chemical warfare agent (CWA) degradation products. This area of research has gained greater importance in recent years. Most CWAs are not persistent and degrade in the open environment. The degradation products are usually polar or ionic; thus, HPLC is considered an ideal separation technique. MS detection offers a sensitive and specific means for quantitative analysis for these compounds. Some of the common designs and strategies of HPLC-MS are discussed as well as the common analytical challenges. Also, specific examples of HPLC-MS applications involving screening procedures are reviewed and described. These procedures utilized both reversed-phase and ion-pair reversed-phase HPLC to separate several alkyl methylphosphonic acids, which are the degradation products of nerve agents. [Description provided by NIOSH]
• Subjects:
  Chemical Warfare Agents Chemistry Chemistry, Analytic Mass Spectrometry Occupational Health Safety
• Keywords:
  Analytical-chemistry; Analytical-processes; Chemical-warfare-agents; Liquid-chromatography; Mass-spectrometry; Author Keywords: HPLC-MS; Sarin; VX; Mustard Gas
• ISBN:
  9781420084597
• Publisher:
  Taylor and Francis
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  386-395
• Volume:
  1
• NIOSHTIC Number:
  nn:20036139
• Citation:
  Encyclopedia of Chromatography, 3rd Edition. Cazes J, ed., Boca Raton, FL: Taylor and Francis, 2009 Oct; 1:386-395
• Editor(s):
  Cazes J
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  False
• Source Full Name:
  Encyclopedia of Chromatography, 3rd Edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248043/cdc_248043_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]