U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Hearing Loss, Lead (Pb) Exposure, and Noise: A Sound Approach to Ototoxicity Exploration



Details

  • Personal Author:
  • Description:
    To determine the state of the research on ototoxic properties of Pb, evaluate possible synergistic effects with concurrent noise exposure, and identify opportunities to improve future research, we performed a review of the peer-reviewed literature to identify studies examining auditory damage due to Pb over the past 50 years. Thirty-eight studies (14 animal and 24 human) were reviewed. Of these, 24 suggested potential ototoxicity due to Pb exposure, while 14 found no evidence of ototoxicity. More animal studies are needed, especially those investigating Pb exposure levels that are occupationally and environmentally relevant to humans. Further investigations into potential interactions of Pb in the auditory system with other hazards and compounds that elicit ototoxicity are also needed in animal models. To better assess the effects of Pb exposure on the human auditory system and the possibility of a synergism with noise, future epidemiological studies need to carefully consider and address four main areas of uncertainty: (1) hearing examination and quantification of hearing loss, (2) Pb exposure evaluation, (3) noise exposure evaluation, and (4) the personal characteristics of those exposed. Two potentially confounding factors, protective factors and mixtures of ototoxicants, also warrant further exploration. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1093-7404
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    335-355
  • Volume:
    21
  • Issue:
    5
  • NIOSHTIC Number:
    nn:20055548
  • Citation:
    J Toxicol Environ Health B 2018 Jul; 21(5):335-355
  • Contact Point Address:
    Richard L. Neitzel, Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights 6611 SPH I, Ann Arbor, MI 48109
  • Email:
    rneitzel@umich.edu
  • CAS Registry Number:
    Lead (CAS RN 7439-92-1)
  • Federal Fiscal Year:
    2018
  • Performing Organization:
    University of Michigan, Ann Arbor
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Journal of Toxicology and Environmental Health, Part B: Critical Reviews
  • End Date:
    20280630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:a4f2ed87d87f37ae06ce1b0eddd169892d722258f0de1f61887e9839a32c69f770fadf70c282520f58a8a5466f75e8aee09342e737b62d96612d0f244623fd2d
  • Download URL:
  • File Type:
    Filetype[PDF - 1.68 MB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP