Hearing Loss, Lead (Pb) Exposure, and Noise: A Sound Approach to Ototoxicity Exploration

Details

• Alternative Title:
  J Toxicol Environ Health B Crit Rev
• Personal Author:
  Carlson, Krystin ; Neitzel, Richard L
• Description:
  To determine the state of the research on ototoxic properties of Pb, evaluate possible synergistic effects with concurrent noise exposure, and identify opportunities to improve future research, we performed a review of the peer-reviewed literature to identify studies examining auditory damage due to Pb over the past 50 years. Thirty-eight studies (14 animal and 24 human) were reviewed. Of these, 24 suggested potential ototoxicity due to Pb exposure, while 14 found no evidence of ototoxicity. More animal studies are needed, especially those investigating Pb exposure levels that are occupationally and environmentally relevant to humans. Further investigations into potential interactions of Pb in the auditory system with other hazards and compounds that elicit ototoxicity are also needed in animal models. To better assess the effects of Pb exposure on the human auditory system and the possibility of a synergism with noise, future epidemiological studies need to carefully consider and address four main areas of uncertainty: (1) hearing examination and quantification of hearing loss, (2) Pb exposure evaluation, (3) noise exposure evaluation, and (4) the personal characteristics of those exposed. Two potentially confounding factors, protective factors and mixtures of ototoxicants, also warrant further exploration.
• Subjects:
  Animals Environmental Exposure Environmental Pollutants Hearing Loss Hearing Loss, Noise-Induced Humans Lead Noise Occupational Exposure
• Keywords:
  Exposure Mixtures Hearing Loss Lead (Pb) Noise Ototoxicity
• Source:
  J Toxicol Environ Health B Crit Rev. 21(5):335-355
• Pubmed ID:
  30663930
• Pubmed Central ID:
  PMC9903337
• Document Type:
  Journal Article
• Funding:
  T32 ES007062/ES/NIEHS NIH HHSUnited States/ ; T42 OH008455/OH/NIOSH CDC HHSUnited States/
• Volume:
  21
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:e82c37a7d12cfc3d56a3701a7841ec3359bebc31ec08cd0e0f8016ee768229c309405bc07d56b5202971f4c18b020602ff3c11557af34f47e41b66cb517a927c
• Download URL:
  https://stacks.cdc.gov/view/cdc/124422/cdc_124422_DS1.pdf
• File Type:
  [PDF - 405.02 KB ]