The Relationship Between Environmental Exposure to Phthalates and Computer-Aided Sperm Analysis Motion Parameters

Details

• Personal Author:
  Brock JW ; Calafat, Antonia M. ; Chen Z ; Duty SM ; Hauser R ; Overstreet J ; Ryan L ; Silva MJ
• Description:
  The general population is exposed to phthalates through consumer products, diet, and medical devices. The present study explored whether phthalates, reproductive toxins in laboratory animals, were associated with altered sperm movement characteris- tics in men. Two-hundred twenty subjects provided a semen sample for computer-aided sperm analysis (CASA) and a urine sample for measurement of phthalate monoesters, monoethyl (MEP), monobenzyl (MBzP), mono-n-butyl (MBP), mono-2-ethylhexyl (MEHP), and monomethyl (MMP). Three CASA parameters, straight-line velocity (VSL), curvilinear velocity (VCL), and linearity (LIN), were used as measures of sperm progression, sperm vigor, and swimming pattern, respectively. There were suggestive dose-response relationships (shown as the predicted change in mean sperm motion parameter for the second and third tertiles compared with the first tertile; P value for trend) for MBzP with VSL (-2.36 um/s, -2.81 um/s; P = .09) and VCL (-1.67 um/s, -2.45 um/s; P = .4). There were suggestive negative associations between MBP and VSL (-3.07 um/s, -2.87 um/ s; P = .08) and VCL (-3.25 um/s, -3.46 um/s; P = .2), and between MEHP with VSL (-1.09 um/s, -2.73 um/s; P = .1) and VCL (-0.29 um/s, -2.93 um/s; P = .3). In contrast to the other phthalates, MEP was positively associated with VSL and VCL but negatively associated with LIN. No consistent relationship was found for MMP and any sperm motion parameter. Although we did not find statistically signif- icant associations, trends between CASA parameters, sperm velocity, and forward progression, and increased urinary levels of MBP, MBzP, and MEHP warrant further follow-up [Description provided by NIOSH]
• Subjects:
  Chemistry Environment Environmental Exposure Epidemiology Hazardous Substances Men Occupational Health Phthalic Acids Safety Urine Urogenital System

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• Keywords:
  Author Keywords: Environment Chemical Properties Chemicals Dose Response Drugs Environmental Exposure Health Effects Human Phthalate Humans Phthalates Reproductive Effects Toxins Urine Chemistry

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• ISSN:
  0196-3635
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-302
• Volume:
  25
• Issue:
  2
• NIOSHTIC Number:
  nn:20055499
• Citation:
  J Androl 2004 Mar-Apr; 25(2):293-302
• Contact Point Address:
  Dr Russ Hauser, Department of Environmental Health, Occupational Health Program, Building 1, Room 1405, 665 Huntington Avenue, Boston, MA 02115
• CAS Registry Number:
  Mono(2-ethylhexyl) phthalate (CAS RN 4376-20-9) ; Monobenzyl phthalate (CAS RN 2528-16-7)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Journal of Andrology
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5df962c53cc7e1b6792aba5c5a3401dd559ae8638ca0c7fc64a1e478a9ffcd90b8a5d9d43cf6ae34eb2a8167aca5179c2a24a802a66356dc6eee33283378c909
• Download URL:
  https://stacks.cdc.gov/view/cdc/213336/cdc_213336_DS1.pdf
• File Type:
  [PDF - 76.22 KB ]