Phthalate Exposure and Reproductive Hormones in Adult Men

Details

• Personal Author:
  Calafat, Antonia M. ; Duty SM ; Hauser R ; Ryan L ; Silva MJ
• Description:
  BACKGROUND: Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the USA. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in adult men. METHODS: Between 1999 and 2003, 295 men were recruited from Massachusetts General Hospital. Selected phthalate metabolites were measured in urine. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including FSH, LH, sex hormone-binding globulin, testosterone, and inhibin B. RESULTS: An interquartile range (IQR) change in monobenzyl phthalate (MBzP) exposure was significantly associated with a 10% [95% confidence interval (CI): -16, -4.0] decrease in FSH concentration. Additionally, an IQR change in monobutyl phthalate (MBP) exposure was associated with a 4.8% (95% CI: 0, 10) increase in inhibin B but this was of borderline significance. CONCLUSIONS: Although we found associations between MBP and MBzP urinary concentrations and altered levels of inhibin B and FSH, the hormone concentrations did not change in the expected patterns. Therefore, it is unclear whether these associations represent physiologically relevant alterations in these hormones, or whether they represent associations found as a result of conducting multiple comparisons. [Description provided by NIOSH]
• Subjects:
  Aging Endocrine System Energy Metabolism Environmental Exposure Epidemiology Hazardous Substances Men Occupational Health Phthalic Acids Safety Urine Urogenital Diseases Urogenital System

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• Keywords:
  Age Groups Author Keywords: Environmental Developmental Disorders Environmental Exposure Hormones Human Humans Metabolites Models Phthalates Physiology Polyvinyl Chloride PVC Regression Analysis Reproductive Effects Reproductive System Disorders Statistical Analysis Toxic Effects Toxins Urinalysis Urine Chemistry

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• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  3
• NIOSHTIC Number:
  nn:20055495
• Citation:
  Hum Reprod 2005 Mar; 20(3):604-610
• Contact Point Address:
  Russ Hauser, Environmental Health Department, Occupational Health Program and Biostatistics Department, Harvard School of Public Health, Boston, MA 02115
• CAS Registry Number:
  Butyl benzyl phthalate (CAS RN 85-68-7) ; Monobenzyl phthalate (CAS RN 2528-16-7) ; Poly(vinyl chloride) (CAS RN 9002-86-2)
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Human Reproduction
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:60bc2d74be7f47a586b613de574041f69746d6fc0bf2fbcf8a8d02504a80aec6474c80f049368a53785032751d55ce6a2b00be20b2e0f24a01fa73c6c1df6f9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/213332/cdc_213332_DS1.pdf
• File Type:
  [PDF - 117.72 KB ]