World Trade Center Particulate Matter-Induced Cardiorespiratory and Vascular Dysfunction (CaRVD) and Obstructive Airways Disease

Details

• Personal Author:
  Crowley G ; Kwon S ; Liu M ; Mueller A ; Nolan A ; Prezant DJ ; Zeig-Owens R
• Description:
  RATIONALE. Airway hyperreactivity(AHR) is associated with at least a 30% increase in cardiovascular risk. Recent prospective studies have demonstrated an association between impaired lung function and central arterial stiffness prior to development of overt vascular disease through systemic inflammation. We have validated cardiovascular disease biomarkers such as MetSyn as predictive of World Trade Center-Lung Injury (WTC-LI) and WTC-AHR. Pulmonary vascular injury may occur prior to the development of abnormal lung mechanics. Prospective studies demonstrated an association between impaired lung function and central arterial stiffness which occur prior to frank vascular disease. METHODS. Prospective longitudinal assessment of BMI, smoking status, medication use, lipids, glucose, vitals, and pulmonary function tests were obtained from the electronic medical record of subjects that completed a WTC-HP assessment since March of 2018. Cardiovascular disease (CVD) was defined as having had a myocardial infarction, stroke, unstable angina, coronary artery surgery/angioplasty, or CVD-related death up till March of 2019. RESULTS. Of N=9,802 firefighters exposed at the WTC site, N=8,784 had complete data. N=1,938 had WTC-OAD (either airway hyperreactivity by positive bronchodilator (improvement of FEV1 by 12% and at least 200mL), methacholine challenge (PC20<16) or WTC-LI(FEV1
• Subjects:
  Biomarkers Firefighters Lung Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Airway Obstruction Cardiovascular Function Fire Fighters Longitudinal Study Lung Function World Trade Center WTC
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  205
• NIOSHTIC Number:
  nn:20066265
• Citation:
  Am J Respir Crit Care Med 2022 May; 205(Abstract Issue):A4789
• Email:
  kwons04@nyumc.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstract Issue
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9cb2f670aef305365a8f77f9e25b3a2e62f8d9084f8463e635d491f8d00c48540a31fc838f47e94d461074a2b57dd0b67faae776d9e9b4a04983328c44c33026
• Download URL:
  https://stacks.cdc.gov/view/cdc/212743/cdc_212743_DS1.pdf
• File Type:
  [PDF - 185.37 KB ]