Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study

Details

• Personal Author:
  Clementi E ; Crowley G ; Kwon S ; Lam R ; Liu M ; Mikhail M ; Nolan A ; Prezant D ; Schwartz T ; Zeig-Owens R
• Description:
  PURPOSE: Airway hyperreactivity (AHR), related to environmental exposure, is a significant public health risk worldwide. Similarly, Metabolic Syndrome (MetSyn), a risk factor of obstructive airway disease and systemic inflammation, is a significant contributor to global adverse health. METHODS: This prospective cohort study followed N=7,486 subjects from 9/11/2001 until 8/1/2017, and investigated N=539 with newly developed AHR for clinical biomarkers of MetSyn and compared them to the non-AHR group. Male firefighters with normal lung function and no AHR pre-9/11 that had blood drawn from 9/11/2001-7/24/2002 were assessed. WTC-AHR was defined as either a positive bronchodilator response or methacholine challenge. We modeled the association of MetSyn characteristics at the first post-9/11 exam with AHR. RESULTS: Those with AHR were significantly more likely to be older, have higher BMIs, have high intensity exposure, and have MetSyn. Smoking history was not associated with WTC-AHR. Those present on the morning of 9/11 had 224% increased risk of developing AHR, and those who arrived in the afternoon of 9/11 had a 75.9% increased risk. CONCLUSIONS: Having =3 MetSyn parameters increased the risk of WTC-AHR by 65.4%. CLINICAL IMPLICATIONS: Co-existing MetSyn and high WTC exposure are predictive of future AHR and suggest that systemic inflammation may be a contributor. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Energy Metabolism Firefighters Lung Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Airway Obstruction Cohort Studies Fire Fighters Longitudinal Study Lung Function Metabolic Effects Respiratory Irritants World Trade Center WTC
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• Issue:
  4
• NIOSHTIC Number:
  nn:20066275
• Citation:
  Chest 2019 Oct; 156(4)(Suppl):A864
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  Chest
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b5f5c882ddec4de218634057046979ed6f3049cc8168efdd5cd7fdfeede169c65031741a93fc04eeb161333b1b57c9447dda8bed3a99bfdd691cac74303c38cc
• Download URL:
  https://stacks.cdc.gov/view/cdc/212753/cdc_212753_DS1.pdf
• File Type:
  [PDF - 91.33 KB ]