World Trade Center Particulate Matter Associated Cardiopulmonary Dysfunction and Injury: Incorporating Echocardiography in a Murine Model

Details

• Personal Author:
  Crowley G ; Nolan A ; Oskuei A ; Vaidyanathan S ; Veerappan A ; Wadghiri YZ
• Description:
  RATIONALE Vascular changes are known to occur early in the development of obstructive airways disease. Vascular serum biomarkers and an elevated pulmonary artery (PA)/aorta ratio are associated with the development of WTC-associated lung disease. The vascular remodeling and the early detection of cardiopulmonary vascular dysfunction due to WTC-PM exposure are not well understood. Clinically relevant non-invasive whole animal imaging may facilitate our understanding of end-organ dysfunction in our murine model of WTC-PM exposure. This study is designed to quantify noninvasive measures of the cardiopulmonary functional changes that may lead to permanent cardiopulmonary vascular remodeling and dysfunction during secondary to WTC-PM. METHIODS C57Bl/6 wild type (WT) mice (n-8/group}, aged 8-10 weeks aspirated 200µg-PM (WTC-Aggregate, PMs3) or PBS. 24-h after exposure, all mice underwent noninvasive in vivo echocardiography (Fujifilm VisualSonics Vevo 3100) to monitor the development of cardiopulmonary functional changes. Trichrome (Gomori) stain for collagen analysis was [performed on 4% parraformaldehyde fixed cardiac tissue sections (5 µm) using imageJ program. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Cohort Studies Firefighters Lung Occupational Health Particulate Matter Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Animal Studies Cardiovascular Function Cohort Studies Fire Fighters Lung Function Particulates World Trade Center WTC
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  199
• NIOSHTIC Number:
  nn:20066277
• Citation:
  Am J Respir Crit Care Med 2019 May; 199(Abstract Issue):A2491
• Email:
  arul.veerappan@nyulangone.org
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstract Issue
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc87a95cd5d8bb53e9e8f9f87ab3bcab36e23e5a9f972966c9ab18e2a74c0c6044ed2fb53fcc62fe4b8eea2b4428b7158c85ab4108eeba99e4a266eec3706b12
• Download URL:
  https://stacks.cdc.gov/view/cdc/212755/cdc_212755_DS1.pdf
• File Type:
  [PDF - 158.67 KB ]