Interleukin-11 Receptor Subunit Alpha-1 Is Required for Maximal Airway Responsiveness to Methacholine After Acute Exposure to Ozone (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Interleukin (IL)-11, a pleiotropic, cationic cytokine, contributes to numerous biological processes, including adipogenesis, hematopoiesis, and inflammation. Asthma, a chronic respiratory disease, is notably characterized by reversible airway obstruction, persistent lung inflammation, and airway hyperresponsiveness (AHR). Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required along with glycoprotein 130 to transduce IL-11 intracellular signaling. Nevertheless, the contribution of IL-11Ra1 to the manifestation of phenotypic features of non-atopic asthma are not presently known. Thus, based on the aforementioned observations, we hypothesized that genetic deficiency of IL-11Ra1 would attenuate lung inflammation and increases in airway responsiveness following acute inhalation exposure to ozone, a criteria pollutant and non-atopic asthma stimulus. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Asthma, Occupational Immune System Lung Occupational Health Ozone Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Cell Signaling Cellular Effects Cytokines Genetic Factors Immune Reaction Inhalation Studies Lung Irritants Respiratory Diseases
• DOI:
  https://doi.org/10.26616/NIOSHRD-1047-2022-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20066166
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1047-2022-0, 2023 Feb; :dataset
• Contact Point Address:
  Pathology and Physiology Research Branch (PPRB), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1000 Frederick Lane, Morgantown, WV, 26508-5402. Tel.: (304) 285-5831
• CAS Registry Number:
  Methacholine (CAS RN 55-92-5) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8794020541d76f5a7c6ba53585dcdc3038a38e8e38c18a7f5b522e03845e8529d6b642197e0ef3442936ed446fea3a2329408c20ef1d9ac47b863f1ba4073584
• Download URL:
  https://stacks.cdc.gov/view/cdc/212671/cdc_212671_DS1.pdf
• File Type:
  [PDF - 134.41 KB ]