Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss

Details

• Personal Author:
  Holmbäck U ; Leproult R ; Van Cauter E
• Description:
  Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Cardiovascular Diseases Cardiovascular System Circadian Rhythm Energy Metabolism Hematologic Diseases Immune System Occupational Health Risk Assessment Risk Factors Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Blood-sugar-disorders Cardiovascular-disease Cardiovascular-function Circadian-rhythms Humans Immune-reaction Metabolism Physiopathology Risk-factors Shift-work Shift-workers Sleep-deprivation Sleep-disorders

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• ISSN:
  0012-1797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  63
• Issue:
  6
• NIOSHTIC Number:
  nn:20045077
• Citation:
  Diabetes 2014 Jun; 63(6):1860-1869
• Contact Point Address:
  Rachel Leproult, Sleep Metabolism and Health Center, Department of Medicine, University of Chicago, Chicago, IL
• Email:
  rleproult@gmail.com
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Diabetes
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4bbacabb5d522992b06137b83de46a0acc87204b95992f74be4c26053b66b1223f7dff4765dba33f2ec43f6f33c9bce25ba00a589556d1ab7efab283fcc21d11
• Download URL:
  https://stacks.cdc.gov/view/cdc/200609/cdc_200609_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]